Project Grant R01MH142612
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $735,182 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate how social interactions promote recovery from viral infections through interleukin-10 (IL-10)–mediated mechanisms. The research uses murine models to explore the neural-immune pathways linking social touch, oxytocin, and IL-10 in recovery from virally induced sickness behaviors. The project will determine...
- The National Institute of Mental Health awarded Yale University $838,378 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural circuits regulating infant social behaviors and learning, with focus on somatostatin-expressing neurons in the zona incerta (ZISST neurons) in preweaning mice. The research comprises three aims. Aim 1 will determine activity dynamics of ZISST neurons in response to maternal behaviors using fiber photometry and...
- The National Institute of Mental Health awarded Yale University $847,792 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop integrated human thalamocortical assembloids that produce thalamocortical oscillations—brain rhythms representing inner states of the brain for vigilance and behavior. The project addresses the lack of tractable models for investigating human brain rhythm mechanisms, which are dysregulated in most neuropsychiatric and neurodegenerative...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- Federal Grant Award Summary Yale University received a $461,084 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded June 16, 2025, with completion targeted for June 15, 2027. The award funds research investigating the cellular and circuit mechanisms underlying age-dependent social behaviors, specifically examining how pro-opiomelanocortin (POMC) neurons in the hypothalamus regulate social interactions during...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $839,815 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a clinical and translational research project investigating neuroimmune mechanisms of depression and anhedonia. The project tests the hypothesis that heightened peripheral immune function and increased blood-brain barrier permeability contribute to major depressive disorder and anhedonia severity. Work is...
- The National Institute of Mental Health awarded Northwestern University $708,139 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how interleukin-4, a cytokine elevated during allergic inflammation, modulates neural circuits underlying avoidance behavior and contributes to mood and anxiety disorders. The project, titled "Cytokine-Mediated Tuning of Neural Circuits Underlying Avoidance Behavior," integrates molecular, cellular, and...
- The National Institute of Mental Health awarded Yale University $157,388 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to functionally characterize somatic mosaic variants in the brains of patients with schizophrenia and autism and determine their causal roles in neurodevelopmental disease. The funded work applies massively parallel reporter assays, CRISPR technology, and human induced pluripotent stem cell-derived neural progenitor cells and post-mitotic neurons...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
The National Institute of Mental Health awarded Yale University $711,168 under Mental Health Research Grants (CFDA 93.242) on September 1, 2026, to identify circuit mechanisms by which insular cortex immune-responsive neurons alter behavior during peripheral inflammation. The project uses mouse models of type 2 and type 3 inflammation combined with single-cell transcriptomics, electrophysiology, and chemogenetics to determine whether insular cortex immune-responsive neurons are heterogeneous and hyperexcitable, examine their stimulus specificity through activity-tagging and in vivo calcium imaging, and characterize their direct connections to brain regions involved in emotional regulation including the amygdala and prefrontal cortex. The research addresses gaps in understanding how peripheral inflammatory challenges drive elevated psychiatric disorder risk in individuals with inflammatory diseases. Performance occurs in New Haven, Connecticut, with a period of performance from September 1, 2026, through June 30, 2031. This is a Project Grant, the standard R01 research award mechanism under NIMH's Mental Health Research Grants program, supporting specified project periods not exceeding five years with potential for renewal as new competing requests.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $711.2k | 9/2/26 |