Project Grant R21MH141409
- The National Institute of Mental Health awarded The University of Chicago $656,448 on August 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms underlying cognitive flexibility and task switching. The research addresses how the brain balances flexibility and stability in routing sensory and contextual information to guide behavior—a balance whose dysfunction characterizes dementia, autism, and substance abuse. The project tests the hypothesis...
- The National Institute of Mental Health awarded Rosalind Franklin University of Medicine & Science $465,301 on July 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how social deprivation during adolescence impairs basomedial amygdala development and compromises social behavior. The research examines the role of the basomedial amygdala in regulating social engagement across developmental stages, with specific focus on how atypical social...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded the University of Illinois $100,228 on September 30, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct qualitative research on implementation of suicide prevention evidence-based practices in outpatient pediatric behavioral health settings. The recipient will recruit pediatric mental health clinicians, youth patients ages 12–18, and patient caregivers from public outpatient child psychiatry clinics to participate in...
- The National Institute of Mental Health awarded the University of Pittsburgh $569,831 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate cortical circuit abnormalities underlying deficits in visual and prefrontal gamma oscillations in schizophrenia. The award funds research combining high-resolution expansion microscopy with multiscale computational modeling to evaluate synaptic mechanisms that disrupt gamma oscillations in schizophrenia. The...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $244,428 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on cholinergic modulation of thalamocortical projections to prefrontal cortex in cognitive flexibility. The research will determine whether acute adult cholinergic modulation in the prefrontal cortex modulates attentional set-shifting performance and whether enhancing...
- The National Institute of Mental Health awarded the University of Illinois $721,485 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and pilot a digital low-intensity mental health treatment technology integrated into Chicago Park District teen programming. The University of Illinois will design and implement the CPKD D-LITE, a digital screening and referral tool targeting adolescents and young adults through the Chicago Park District, which serves more...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $800,384 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct molecular and functional dissection of prefrontal-hippocampal long-range inhibition. The project investigates a novel long-range GABAergic pathway from prefrontal cortex to hippocampus that mediates top-down control of hippocampal function. The research will elucidate mechanisms through...
The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social behaviors during adolescence, and conversely, how disruption of these developmental processes may underlie the emergence of psychiatric disorders. The project focuses on identifying prefrontal and hippocampal circuits subject to plasticity during this developmental window and determining how refinement of the excitation-inhibition ratio in each structure supports normal behavioral transitions into adulthood. A particular emphasis is the role of parvalbumin-positive interneurons, whose reduced expression has been consistently observed in neurodevelopmental disorders including schizophrenia and autism. The award carries a period of performance from July 27, 2026, to June 30, 2028, with place of performance in Chicago, Illinois. This is a project grant (Assistance Listing assistance type); the award is obligated in full at $440,908.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.9k | 7/29/26 |