Project Grant R03HL183275
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Pennsylvania a $5.03M Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective September 1, 2025, through August 31, 2029, to conduct the EXFIN-TB study investigating excess cardiovascular inflammation in tuberculosis (TB) and human immunodeficiency virus (HIV) survivors. The research addresses the critical public health problem that TB survivors face a 3-fold increased risk...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a $514,484 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) on August 24, 2025, for research investigating the role of kynurenine pathway metabolism in pulmonary arterial hypertension (PAH). The research will be conducted through June 30, 2030, at Johns Hopkins' Maryland facilities. The project delivers basic and translational research services focused on...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $897,448 Project Grant on September 18, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to establish a prospective population-based cohort study examining the causality of post-tuberculosis (TB) lung disease in rural Uganda. The research will leverage an existing cohort of 9,000 participants already undergoing lung function...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $1,299,500 Project Grant effective July 1, 2025 through June 30, 2027 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project, conducted in Baltimore, Maryland, focuses on developing and utilizing novel positron emission tomography (PET)-based imaging methodologies to assess post-tuberculosis (TB) lung disease in TB patients...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $3.14 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 19, 2025, with a completion date of August 31, 2029. This award supports basic biomedical research investigating macrophage senescence as a driver of granuloma failure and progression to necrosis in tuberculosis (TB) and TB/HIV co-infection. The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Harvard Medical School a $2.49 million Project Grant on September 20, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a longitudinal cohort study evaluating post-tuberculosis lung disease (PTLD) among successfully treated TB patients in Lima, Peru. The research will leverage an existing NIH-funded cohort to assess 1,000 TB patients and 291 community controls at 2–3 years...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a Project Grant of $638,176 (Award Date: May 1, 2026; Completion Date: February 28, 2029) under the Cardiovascular Diseases Research program (CFDA 93.837). This grant funds basic research investigating thrombospondin-1 (TSP-1), a matricellular protein, as a therapeutic target for treating heart failure with preserved ejection fraction (HFpEF). The research will examine the...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a $180,488 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) effective March 1, 2026, through September 15, 2027, to conduct research on severe acute respiratory failure (ARF) following immune checkpoint inhibitor (ICI) therapy. The research will identify clinical and biomarker risk factors associated with ARF in ICI-treated cancer patients and evaluate...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $788,478 Project Grant to the University of Texas Medical Branch at Galveston effective September 1, 2025, through June 30, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds basic research investigating how C-type lectin receptor (CLR) signaling, specifically through the macrophage galactose-type lectin (MGL/CLEC10A), regulates immune metabolism and...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a $174,488 Project Grant effective February 19, 2026, through December 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). This research grant supports an investigator-training initiative to elucidate the molecular mechanisms by which mitogen-activated protein kinase activated protein kinase 2 (MK2) regulates endothelial cell apoptosis during barrier...
The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a Project Grant of $194,094 (CFDA 93.837, Cardiovascular Diseases Research) effective June 1, 2026 through May 31, 2028 to conduct research on tuberculosis (TB) disclosure and stigma in the context of TB care. The project will deliver research findings and evidence addressing how TB-related stigma and disclosure behaviors impact treatment outcomes and contact investigation effectiveness. This research directly supports the World Health Organization's priority to combat TB stigma as a critical component of achieving the End TB targets—reducing global TB incidence by 80% and deaths by 90% by 2030. The research builds upon preliminary qualitative work from the principal investigator's current K01 award in South Africa and prior large-scale contact investigation trials. The project will generate insights into the interplay between TB stigma, patient disclosure to close contacts, and barriers to TB contact investigation—a key intervention that disrupts TB transmission by identifying new cases earlier and preventing secondary transmission. The deliverables will include research findings that address the substantial gap in TB contact investigation participation rates (currently 60% in prior trials) and inform evidence-based interventions to improve disclosure and engagement in TB care cascades, particularly in low- and middle-income settings.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.1k | 5/28/26 |