Project Grant R01HL181469
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $457,513 to the University of Texas at Arlington (UTA) to investigate the role of the enzyme indoleamine-2,3-dioxygenase 1 (IDO1) and its downstream metabolite kynurenine in regulating cholesterol homeostasis and macrophage function under inflammatory conditions. The 3-year project aims to elucidate the signaling mechanisms...
- This $811,396 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases under CFDA 93.855 Allergy and Infectious Diseases Research, is focused on understanding the mechanisms of lipid/metabolite and drug transport in Mycobacterium tuberculosis and related mycobacteria. The major objectives are to establish the molecular mechanisms and structures of three specific MMPL transporter proteins and their complexes with interacting partner proteins. Key activities include...
- This $450,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Arkansas for Medical Sciences (UAMS) aims to enhance the understanding of macrophage subsets in tuberculosis (TB) infection and lesion biology. The project will leverage the C3HeB/FeJ mouse model, which forms the caseous necrotic lesions observed in human TB, to investigate how different lung macrophage subsets influence...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,513,201 in funding to The Trustees of the University of Pennsylvania to research excess cardiovascular inflammation in tuberculosis (TB) and HIV. The overarching hypothesis is that TB promotes pulmonary inflammation leading to subclinical vascular pathology, increasing the risk of major cardiovascular events in TB survivors. The research will investigate...
- This $162,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to characterize the role of plasmacytoid dendritic cells (PDCs) in Mycobacterium tuberculosis (MTB) infection. The research aims to quantify PDC trafficking and activation in the lungs during MTB infection, and determine how PDC-driven type I interferon responses impact MTB control. The project will leverage a mouse model that...
- This $227,096 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Berkeley to investigate nutrient acquisition strategies utilized by the tuberculosis pathogen Mycobacterium tuberculosis (MTB) during infection of human macrophages. The researchers have developed a novel genetic screening technique called Random Barcode Transposon Site Sequencing (RB-TnSeq) to...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $161,890 to the University of Washington (UW) to support research on the role of alveolar macrophages in the host response to gram-negative bacterial pulmonary infections, such as those caused by Burkholderia pseudomallei. The research aims to elucidate the significance of alveolar macrophages as an intracellular replication niche for Burkholderia species, as well...
- This Project Grant award for $1,063,324 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on CD4+ T cell immunity in the respiratory tract, with a focus on understanding the mechanisms underlying host defense against extracellular pathogens, particularly in the area of Type 17 cytokines and tissue resident memory CD4+ T cells. The research will utilize murine and primate respiratory tract samples to assess the metabolic...
- This Project Grant award of $104,262, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to explore the relationship between genetic variants, transcriptional responses, and tuberculosis (TB) infection outcomes in macrophages derived from genetically diverse mice. The project aims to understand the basis for variability in TB infection outcomes, which may help identify ways to...
- This $209,408 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports a research project to characterize the role of unconventional T cell subsets in the immune response to Mycobacterium tuberculosis (MTB) infection using a non-human primate model. The goal is to gain a better understanding of these niche T cell populations in the lung granulomas during the early stages of MTB...
This federal Project Grant award of $788,478 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Texas Medical Branch at Galveston (UTMB) to investigate the role of C-type lectin receptor (CLR) signaling through the macrophage galactose-type lectin (MGL) in regulating macrophage immune metabolism and the host lipid response during Mycobacterium tuberculosis (MTB) infection. The research aims to 1) identify how MGL regulates the lipid response of pulmonary macrophages to MTB, 2) demonstrate the role of MGL pathways in determining macrophage polarization in response to mycobacteria, and 3) elucidate the mechanism by which MGL pathways influence macrophage function. This work will advance the scientific understanding of how CLR signaling can modulate immune responses and metabolic reprogramming in the context of tuberculosis, with potential implications for developing host-directed therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $788.5k | 8/21/25 |