This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the mechanistic basis for interactions between migrating cells and their tissue substrates. Specifically, the $142,996 award aims to investigate how migrating caudal visceral mesoderm (CVM) cells in Drosophila nonautonomously modulate the directional growth of...
This $378,123 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish the transcriptional regulatory potency of early embryos. The award to the Research Foundation of the City University of New York (RFCUNY) for the College of Staten Island will utilize various genomic profiling techniques,...
The federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $104,838 to Duke University to conduct research on understanding how cells interpret and respond to varying inputs from the BMP signaling pathway, which plays a critical role in embryonic development and tissue health. The key products or services to be delivered under this award include:...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to study the role of the NSUN2 RNA methyltransferase in regulating translation and pluripotency in stem cells. The $205,625 award, granted to The Trustees of Columbia University in the City of New York, will fund research to identify NSUN2-modified RNA targets and explore how NSUN2-mediated RNA methylation...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to explore the signaling mechanisms and functional roles of the calcium-sensing receptor (CaSR) in human health and disease. The $246,750 award to The Trustees of Columbia University in the City of New York will support structure-based functional studies to understand how CaSR achieves G...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a research project titled "Chromatin Factor Regulation of Neuroblast Progenitor Genome Dynamics" at The Trustees of Columbia University in the City of New York. The $454,717 project will run from July 1, 2024 to June 30, 2029 and aims to investigate how the three-dimensional organization of the neural progenitor genome...
This $157,500 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research at The Ohio State University to investigate how systemic signaling pathways coordinate with local growth and patterning mechanisms during the early development of the Drosophila (fruit fly) wing. The research aims to identify the specific systemic signals, such as insulin signaling,...
This Project Grant award, valued at $160,877.00, is funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will support research to investigate the role of histone demethylase enzymes KDM3A and KDM3B in the epigenetic reprogramming of primordial germ cells during mouse embryonic development. The research will utilize an in vitro PGC-like cell differentiation model and...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $138,618 to the University of California, Irvine to support research on how gene regulatory redundancy ensures robustness of mammalian development. The research aims to identify the distinct transcription factors driving each "shadow enhancer" and characterize how these enhancers...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $2,720,800 in funding to Brigham & Women's Hospital Inc. to conduct research on the epigenetic regulation of transcriptional programming. The research will focus on understanding the dynamic competition between Polycomb (PcG) and Trithorax Group (TrxG) proteins, and how this impacts cell type-specific...