This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $857,958 will support research to assess autonomic nervous system (ANS) regulation and its link to gastrointestinal disorders in children. The primary awardee, The Medical College of Wisconsin, Inc., will develop an ANS-sensing system to measure vagal efficiency and evaluate the efficacy of personalized...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $196,940 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct a 5-year study on a positive psychology intervention for irritable bowel syndrome (IBS). The project aims to examine the feasibility, acceptability, and preliminary efficacy of a 9-week phone-based positive...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,506,686 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Children's Research Institute. The purpose of this 5-year project is to conduct a pragmatic clinical trial evaluating the efficacy of a mindfulness-based intervention (BREATHE-T1D) compared to a health education program (HEALTHED-T1D) for improving mood and treatment adherence in adolescents...
This Project Grant award, totaling $233,600.00 and spanning September 1, 2024 to June 30, 2027, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD), a debilitating condition characterized by chronic inflammation and erosion of intestinal functions. The...
This Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to delineate the role of substance P-mediated activation of mast cells in irritable bowel syndrome (IBS) pathophysiology. The key objectives are to determine the mechanisms of substance P-induced colonic mast cell activation and elucidate the contributions of mast...
This $475,605 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to definitively evaluate gastric dysrhythmia as a disease mechanism underlying functional dyspepsia and chronic nausea/vomiting syndromes, which affect over 10% of the population. The project will apply a novel non-invasive diagnostic approach called Body...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will provide $254,604 to the Dana-Farber Cancer Institute, Inc. to develop and test a collaborative care model to deliver a resilience intervention for adolescents and young adults (AYAs) with sickle cell disease. The award aims to enhance the PI's skills in collecting and analyzing social determinants of health data, develop expertise in dissemination and implementation...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides approximately $2.4 million over 3 years to the Benaroya Research Institute at Virginia Mason to investigate how genetic variants impact the function of pathogenic T cells in inflammatory bowel diseases (IBDs). The key research activities involve: Performing massively parallel...
This Project Grant award of $209,832, awarded on January 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), will support a 5-year research project led by the New York University School of Medicine. The primary goals are to: 1) Deeply phenotype autonomic dysfunction in chronic kidney disease (CKD) using comprehensive testing, 2) Quantify the association between inflammation and autonomic...
The University of Connecticut received a $1,941,591 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) to develop an objective integrated multimodal electrophysiological (OIME) index that quantifies the level of visceral pain in patients with irritable bowel syndrome (IBS). The key products/services to be delivered under this 5-year award include: Establishing the OIME index...