Project Grant K24HL173664

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $255K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This federal Project Grant award of $827,753.90, awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of thiol isomerases in promoting redox-sensitive vaso-occlusion in sickle cell disease (SCD). The award enables the awardee, Bloodworks, an independent nonprofit organization in Seattle, to conduct a multi-year research project focused on mechanistically examining how thiol...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $608,126 to the Regents of the University of Minnesota to conduct research on discovery and validation of single cell biomarkers for clinical outcomes in sickle cell disease. The primary objectives are to: 1) define the relationship between sickle cell disease adverse clinical outcomes and single cell biochemical and mechanical properties...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $172,176 Project Grant to Albert Einstein College of Medicine to conduct a pilot study titled "Reducing Morbidity in Sickle Cell Disease-PREVENT Acute Chest Syndrome System (PACSYSTEM) Pilot Study." This 5-year grant, awarded on June 1, 2024, aims to improve health outcomes for children and youth with sickle cell disease by using implementation science methods to address barriers and enablers faced by healthcare...
This $159,432 Project Grant award from the National Institute of Nursing Research (CFDA 93.361 Nursing Research) will support the adaptation and pilot testing of the SBAR3 patient-provider communication intervention for adults with sickle cell disease (SCD). The project aims to (1) assess the communication needs of SCD patients, (2) adapt the SBAR3 intervention to meet those needs, and (3) evaluate the feasibility and acceptability of the adapted intervention in a randomized controlled trial....
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $637,526 to Duke University to conduct research on the effects of sickle red blood cells (RBCs) on neutrophil activation and phenotypes in sickle cell disease. The research aims to delineate the specific characteristics of sickle RBCs that induce neutrophil activation, as well as the downstream consequences of these sickle...
This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to define the physiology of blood cell production in the bone marrow tissue during homeostasis, inflammation, and regeneration. The $1,123,357 award, with a project period from January 1, 2025 to December 31, 2031, will enable researchers at the Childrens Hospital Medical Center in Cincinnati, Ohio to: 1) dissect the...
This $445,000 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837) supports research to characterize the role of neutrophil extracellular traps (NETs) in immune homeostasis and explore the potential of NET-directed therapeutics for thromboinflammatory diseases. The three specific aims of the project are: 1) to clarify the role of NETs in host defense, 2) to define the mechanisms by which platelet factor...
This $586,021 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research to establish patient-reported outcome measures that refine risk stratification and identify barriers to post-discharge specialty care for preterm infants with bronchopulmonary dysplasia (BPD). The goal is to use mobile health strategies to link NICU data to parent-reported outcomes from pre-discharge through...
This federal Project Grant award, valued at $179,280, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant aims to investigate how early life nutritional stress, particularly exposure to high-fat diet, impacts neutrophil development and function in the context of sickle cell disease (SCD). The research under this award seeks to evaluate the correlation between diet, disease severity, and neutrophil...
The University of Illinois received a $607,535 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective September 17, 2024 through August 31, 2025, supports research to evaluate the effects of hemin, a breakdown product of cell-free hemoglobin, on the pulmonary endothelium and its contribution to the acute and chronic pulmonary complications of sickle cell disease. The research aims to...

This federal Project Grant award of $254,604 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop and implement a collaborative care model to deliver a resilience-building intervention for adolescents and young adults (AYAs) with non-malignant blood disorders, such as sickle cell disease. The key activities include:

  1. Assessing the feasibility and acceptability of the "Promoting Resilience in Stress Management (PRISM)" intervention delivered through a community-based collaborative care model for 25 AYAs with sickle cell disease.

  2. Leveraging electronic health records to characterize the relationships between social determinants of health and outcomes among youth with non-malignant blood disorders.

  3. Examining how social determinants of health impact the efficacy of existing resilience-focused interventions using data from the Principal Investigator's prior R01-funded trials.

The overarching goal is to improve the physical, emotional, and social quality of life for AYAs with serious blood disorders by developing scalable, evidence-based psychosocial interventions and understanding how social factors influence their effectiveness. The award period is September 1, 2024 to August 31, 2029.

Generated 6/10/25, 3:55 AM