Project Grant R01DK140255

Award Date 7/16/24
Completion Date 4/30/29
Dollars Obligated $431K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Milwaukee, WI 53226, USA
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This federal Project Grant award for $430,707, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to assess autonomic nervous system (ANS) regulation in children with nausea, vomiting, and ANS imbalance. The grant's primary objectives are to:

  1. Develop an ANS-sensing system (ANS-SS) software to measure real-time autonomic regulation, particularly vagal efficiency, in response to percutaneous electrical nerve field stimulation (PENFS) therapy.

  2. Investigate the clinical efficacy and ANS changes of personalized PENFS therapy, with and without gut-directed hypnotherapy, compared to standard pharmacotherapy for these conditions.

The grant involves sub-awards to The Ohio State University and Indiana University to support the research activities. This project aims to advance understanding of brain-gut axis dysregulation in disorders of gut-brain interaction and develop targeted therapies to restore autonomic balance.

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