This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides approximately $2.4 million over 3 years to the Benaroya Research Institute at Virginia Mason to investigate how genetic variants impact the function of pathogenic T cells in inflammatory bowel diseases (IBDs). The key research activities involve: Performing massively parallel...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $151,643 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Colorado-Denver. The grant supports research to develop proteolysis targeting chimeras (PROTACs) that can stabilize hypoxia-inducible factors (HIF) to enhance barrier formation and wound healing in inflammatory bowel disease models. The project aims to elucidate the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $533,907.00 to Rutgers, The State University to investigate the role of the epigenetic regulator TET3 in protecting intestinal epithelial cells against inflammatory stressors. The project aims to decipher the mechanisms by which TET3-mediated DNA oxidation and transcriptional...
This Project Grant award of $1,328,326.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the regulation of CD39 expression in gamma delta intraepithelial lymphocytes (gd IELs) and its impact on immunometabolism and function. The research aims to elucidate the mechanisms by which CD39 expression is regulated in gd IELs, understand the coupling between CD39 and gd IEL...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $584,750 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Foli Bio Inc. on September 17, 2024. The grant will fund the development and validation of Foli Bio's "EXFO-SEQ" technology, a non-invasive platform to analyze the exfoliome (RNA content exfoliated from intestinal cells) in stool samples. The goal is to generate insights into gene expression...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) for $516,648 supports research to investigate whether intestinal stem cells (ISCs) maintain an "inflammatory memory" following exposure to helminth infection, and how this impacts their regenerative capacity. The funded project, led by investigators at the University of California, San Francisco (UCSF), aims to...
This Project Grant award, ID R01DK137771, is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program. The $1,882,623 award will support research at the Cincinnati Children's Hospital Medical Center to investigate the epigenetic regulation of intestinal tuft cells and how microbial metabolites influence their development and function. The research aims to uncover novel...
This Project Grant award, totaling $177,310, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The primary goal of the project is to elucidate the transcriptional regulation and function of the nuclear receptor NR2F6 in T helper 17 (Th17) cells, which play a critical role in inflammatory bowel disease (IBD) and other autoimmune conditions. The research will use...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,060,675 to the University of Arizona to conduct research on the impact of the Absent in Melanoma 2 (AIM2) gene on intestinal stem cell differentiation during inflammation. The research aims to identify novel innate immune targets, cellular signaling pathways, and microbial triggers that can redirect immune...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) provides $858,460 in funding to The Leland Stanford Junior University to research the role of impaired cellular RNA editing as a cause of inflammation in inflammatory bowel disease (IBD). The key objectives are to: 1) Leverage genetic data to prioritize double-stranded RNA (dsRNA) loci for IBD susceptibility and...