Project Grant R03DE035551
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of California, Los Angeles $180,943.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 13, 2025, for research addressing therapeutic targeting of apical periodontal T-cells in chronic oral inflammation. The research initiative, which extends through May 31, 2030, investigates the pathogenic mechanisms underlying apical periodontitis—a chronic...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $540,629 to the University of Massachusetts Lowell on August 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research investigating human oral host-pathogen interactions and dysbiosis modulation. The project, scheduled for completion by August 14, 2027, focuses on developing and validating an immunocompetent three-dimensional (3D) in vitro model...
- Federal Project Grant Award Summary Loma Linda University received a $358,823 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded September 11, 2025, with a completion date of September 10, 2027. The grant funds structural-functional research on gingipain biogenesis and localization in Porphyromonas gingivalis, a keystone pathogen in periodontal disease. The research addresses a...
- Federal Project Grant Award Summary The University of Washington received a $622,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 1, 2025 through July 31, 2027. The award supports a research project titled "Characterizing the Microbial and Inflammatory State Within Distant Clinically Healthy Tissues in Patients with Active Periodontal Disease." The...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a Project Grant of $342,178 on September 11, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop innovative diagnostic technologies for periodontal disease detection. The research initiative will establish quantitative ultrasound (QUS)-derived biomarkers and machine learning classifiers to characterize inflammatory...
- Federal Grant Award Summary The University of Maryland, Baltimore received a $155,500 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period of June 1, 2025 through May 31, 2027. The award funds research focused on elucidating the roles of ENPP1 (ectonucleotide pyrophosphatase phosphodiesterase 1) and ATP metabolism in cementogenesis—the biological process of cementum formation. The...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Florida a $307,000 Project Grant effective July 15, 2025, through July 14, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative investigates the expression of cellular senescence markers in gingival tissue biopsies to elucidate the mechanisms by which Type 2 diabetes mellitus (T2DM) contributes to periodontal disease...
- Federal Grant Award Summary The University of Iowa received a $1,398,368 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective January 15, 2026, with a completion date of December 31, 2030. This research initiative will investigate the mechanisms linking metabolic syndrome (MetS) to periodontal health through a longitudinal systems biology approach. The project will deliver...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Illinois a Project Grant of $217,100.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) effective March 1, 2030. This award supports a structured training and research initiative designed to develop the applicant as a clinician-scientist in craniofacial and oral sciences. The program delivers mentoring, career development support, and professional...
The University of Illinois received a $320,660 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective April 6, 2026, through April 5, 2028. The project, "Elucidating the Immunoregulatory Role of Dendritic Cell Subsets in Periodontal Disease," delivers research services investigating how different dendritic cell (DC) subsets—myeloid DCs, lymphoid DCs, and plasmacytoid DCs—function in periodontal disease development and resolution. The research encompasses ex vivo analysis of human gingival biopsies collected before and after non-surgical periodontal therapy, with particular focus on how periopathic bacteria such as Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis impair DC functionality. The deliverables include systematic evaluation of dendritic cell antigen processing, antigen presentation, phagocytosis, and Type I interferon immune response functions in the presence of periodontal pathogens. By elucidating the dynamic interactions between dendritic cell subsets and bacterial virulence factors, this research aims to generate mechanistic insights that could inform the development of novel therapeutic interventions for periodontal disease, which affects approximately 750 million people worldwide. The two-year project conducted at the University of Illinois Chicago location represents a fundamental contribution to understanding immune cell dysfunction in chronic oral inflammatory disease.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $320.7k | 4/7/26 |