This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $381,216 to conduct research on the role of the ectonucleotidase CD73 in periodontal health and disease. The research aims to delineate how CD73 deficiency leads to metabolic dysfunction and inflammation in gingival fibroblasts, and study how this impacts the stromal-osteoclast axis and influences periodontal...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $249,000.00 to the University of Illinois to conduct research on the structure, biology, and biomechanics of cementum as a function of aging and periodontal disease. The key objectives are to: 1) identify the biochemical, structural, and mechanical features of aging cementum; 2) define the state of...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $690,340 to the University of Southern California to study the role of phosphate transport in enamel formation. The key objectives are to use genetic mouse models to: Examine the contributions of the phosphate importer PIT1 and the phosphate exporters NAPI2B and XPR1 on enamel mineralization during the secretory...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports comprehensive research focused on understanding, preventing, and treating periodontal diseases. The total funding amount is $557,606.00, awarded on April 16, 2025, with an ultimate completion date of March 31, 2030. The key objective of this project is to elucidate the cellular and molecular mechanisms...
This $1,705,144 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies for endogenous periodontal regeneration. The key objectives are: 1) identifying specific cell surface markers to isolate and characterize human PRX1-expressing periodontal ligament stem cells (hPRX1-PCs), 2) developing a strategy to harness these stem cells to induce complete...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $456,500.00 to the University of Southern California to research periodontal tissue regeneration using supramolecular nanomaterials. The key objectives are to investigate how the amelogenin peptide LRAP can activate the canonical Wnt/β-catenin signaling pathway to stimulate the proliferation, migration, and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $109,548 to the University of Pittsburgh to investigate the interactions between phosphorylated amelogenin and acid phosphatase 4 (ACP4) expression in the development of enamel. The research aims to understand the mechanisms of amelogenin phosphorylation and its relationship with ACP4, which is upregulated in mice lacking...
The Project Grant award R43DE033577, with a total funding of $304,019, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The award is for the development of a novel antibody-based therapy to prevent alveolar bone loss in severe periodontitis, a leading cause of tooth loss. The project, conducted by Panorama Research Incorporated, aims to identify and evaluate a panel of human...
This $451,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the molecular mechanisms regulating the expression and activity of the calcium transporter SLC24A4 in ameloblasts during enamel formation. The two key objectives are: 1) Determine the developmental cues and epigenetic factors that upregulate SLC24A4 transcription in maturation ameloblasts,...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Medical University of South Carolina (MUSC) for the period of May 1, 2025 to April 30, 2027. The purpose of this grant is to investigate how oral bacterial pathogens influence aging-associated immune responses and determine if inhibition of the CD38 signaling pathway can attenuate inflammatory bone loss and alleviate aging-related...