This $619,304.36 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop and apply tools to precisely modulate the dosage of transcription factors involved in craniofacial development. The research, to be conducted by The Children's Hospital Corporation (dba Boston Children's Hospital), will focus initially on the transcription factor SOX9, examining which regulatory...
This federal Project Grant award for $148,176.00, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Program (CFDA 93.121), will fund research to uncover novel gene regulatory networks underlying specialized craniofacial development in a new model system of pupfishes. The study will combine tissue-specific differential gene expression analysis and genome-wide chromatin accessibility studies across three developmental...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,000 over a 2-year period from September 2024 to September 2026. The objective is to advance the understanding of craniofacial cartilage differentiation from human neural crest stem cells in 3D cell culture models. The research aims to develop methods for generating functional, transplantable craniofacial cartilage...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $521,209.45 to investigate the role of the transcriptional repressor ZEB2 in human neural crest cell formation and its relationship to Mowat-Wilson syndrome, a rare genetic disorder. The key objectives of this 3-year project are to: 1) examine how ZEB2 regulates TGF-beta signaling during normal human cranial...
This federal Project Grant award, valued at $889,616.00 and provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Program (CFDA 93.121), supports research on RNA localization in neural crest migratory protrusions. The primary grantee, the Regents of the University of Minnesota, will conduct studies to test the hypotheses that specific mRNAs are enriched in neural crest cell (NCC) protrusions and are required for NCC...
This Federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to investigate the genomic and developmental mechanisms underlying Six2-related frontonasal dysplasia, a congenital craniofacial disorder. The $622,608 award, with a period of performance from September 10, 2024 to May 31, 2029, will support research conducted by the Children's Hospital Medical...
This $2,055,996 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a research program led by Dr. Noriaki Ono at the University of Texas Health Science Center at Houston (UTHealth) to investigate skeletal stem cell plasticity in craniofacial bone diseases. The research program consists of three interconnected projects: Examining the roles of periosteal and endosteal stem cells...
This Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, will fund research into the genetic basis of human skeletal facial morphology through July 2025. Provided under the Oral Diseases and Disorders Research program (CFDA 93.121), the $936,510 in funding will support two key aims. First, the awardee will enhance current mesh landmarking procedures for craniofacial bone by developing a dense quasi-landmark...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $130,122 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of North Carolina at Chapel Hill (UNC-CH). The project, titled "Investigating the Roles of the H3K4 Methyltransferases KMT2C and KMT2D in Chondrocyte Differentiation and Endochondral Ossification," will leverage genomic methodologies to examine the molecular mechanisms by which the...
This $123,585 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to decipher the underlying mechanisms of craniofacial spliceosomopathies, a class of rare genetic disorders affecting craniofacial and limb development. The research, conducted by New York University, will leverage a Xenopus tropicalis SF3B4 mutant line and Nager syndrome patient-derived...
This federal Project Grant award, titled "The Role of SOXe Transcription Factors in Neural Crest Cell Specialization," is provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121).
The $821,236.30 award, starting on September 16, 2024 and ending on August 31, 2027, will support research to investigate how SOXe transcription factors contribute to the specialization of neural crest cells, which are critical for craniofacial development. The research will leverage omics approaches, gain/loss-of-function experiments, and SOX9-SOX10 chimera constructs to determine the timing and mechanisms of SOXe-mediated neural crest specialization. This work aims to identify novel SOXe transcriptional targets, understand how specific patient variants in SOX9 and SOX10 cause craniofacial disorders, and provide evolutionary insights into neural crest diversification. The project will be conducted by the University of Kentucky Research Foundation, a non-profit subsidiary of the University of Kentucky that has extensive experience managing federal research grants and contracts.