Project Grant R03DE034716
- Federal Grant Award Summary The University of Pittsburgh received a $679,631 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded February 15, 2026, with a completion date of January 31, 2031. This research initiative addresses peri-implantitis (PI), an inflammatory oral condition affecting approximately 5-10% of the 500,000 dental implants placed annually in the United States. The...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pittsburgh a $454,002 Project Grant on September 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a two-year research initiative examining the dichotomy of phosphate actions in periodontal health. The research will investigate the interplay between dietary phosphate availability, its pro-osteogenic and pro-inflammatory effects, and...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pittsburgh a $1,287,163 Project Grant on August 14, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to advance the genomics knowledge base for oral diseases. The award supports the establishment of a large-scale research consortium comprising more than 800,000 research participants across at least 27 studies to conduct genome-wide association scans...
- Federal Project Grant Award Summary The University of Pittsburgh received a $100,676 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded December 19, 2025, with completion targeted for August 31, 2027. This research project develops a multimodal microelectrode array (MEA) system to investigate tooth root organoid maturation and sensory nerve innervation. The research addresses a...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pennsylvania a $522,405 Project Grant, effective May 1, 2026 through April 30, 2031, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative investigates the role of taste receptor cells—specifically solitary chemosensory cells (SCCs) and macrophages—in periodontal homeostasis and disease prevention. The project delivers basic and...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pittsburgh a $1.9 million Project Grant on September 19, 2025, through the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a three-year research initiative examining head and neck squamous cell carcinoma (HNSCC) outcomes. The research will analyze high-dimensional genomic datasets from public databases using systems biology modeling to identify...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a $429,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective June 5, 2026, with completion targeted for June 8, 2028. The award funds research investigating the effects of recurrent periodontitis on hematopoietic stem cell (HSC) function and systemic health outcomes. The research will establish a chronic...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Pennsylvania a $1,023,156 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) on August 21, 2025, with a completion date of May 31, 2030. This research project investigates bitter taste G protein-coupled receptors (T2Rs) as therapeutic targets in oral squamous cell carcinomas (OSCCs), which carry approximately 50% five-year mortality rates. The funded research...
- Federal Project Grant Award Summary The Pennsylvania State University received a $198,000 Project Grant (R21) awarded on July 1, 2025, by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The two-year research initiative, concluding June 30, 2027, integrates population-wide oral microbiome data from 6,224 adults across four ethnicities participating in the National Health and Nutrition Examination Survey...
- Federal Grant Award Summary The University of Washington received a $622,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 1, 2025, through July 31, 2027. The project, "Characterizing the Microbial and Inflammatory State Within Distant Clinically Healthy Tissues in Patients with Active Periodontal Disease," will deliver single-cell RNA sequencing...
The University of Pittsburgh received a $311,687 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on June 10, 2026, with completion targeted for June 9, 2028. This research initiative investigates the mechanisms of age-related inflammatory dysregulation in periodontal disease pathogenesis, with particular focus on the role of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) in macrophage-mediated immune regulation within the periodontium. The research addresses a critical gap in understanding why periodontal disease prevalence increases with age and seeks to identify therapeutic targets for improved disease management in older adults. The project deliverables include basic research findings on TREM2 signaling pathways, mechanistic data on age-related changes in periodontal macrophage function, and preclinical evidence from mouse models demonstrating the relationship between TREM2 dysregulation and inflammatory disease progression. Preliminary work has established that TREM2 expression decreases in aging periodontium and correlates with increased inflammatory dysregulation and disease severity, providing the scientific foundation for the two-year investigation. The research is conducted at the University of Pittsburgh's Pittsburgh, Pennsylvania facility and contributes to NIDCR's mission to advance fundamental knowledge of dental, oral, and craniofacial health through translational and clinical research methodologies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $311.7k | 6/11/26 |