This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program project grant, awarded to The Pennsylvania State University, will reconstruct the history of the human oral microbiome on a global scale. The $499,996 award, effective July 1, 2025 through June 30, 2028, aims to understand the evolutionary mechanisms that drive human microbiome diversity. The project will explore how bacterial species and microbial communities have adapted or disappeared from the human microbiome...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $999,776.00 to the University of Utah to advance oral health equity through integrated patient, provider, and population-based research approaches. The goal is to strengthen the scientific basis for innovative population-level strategies to improve dental care access, utilization, and quality, particularly for...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $3,465,577.00 to examine the influences of socioeconomic stressors and education-related opportunities on oral health outcomes among a diverse cohort of emerging adults. The project aims to: 1) assess the impact of early adulthood socioeconomic factors on oral health over time, 2) examine how education-related...
This Project Grant award of $155,500 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a comprehensive examination of the oral virome and its interactions with the oral microbiome. The research aims to shed light on the role of viruses in maintaining oral health and contributing to disease, with the goal of illuminating a neglected aspect of the oral microenvironment and potentially...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...
This $314,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to gain insights into the evolution of fungal resistance in the oral environment of HIV-positive individuals. The research will leverage an existing patient dataset to: 1) use long-read sequencing to profile the fungal mycobiome in patient saliva and caries samples, and 2) perform longitudinal...
This $157,500 Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a one-year longitudinal study of the oral microbiome changes in HIV-exposed uninfected (HEU), HIV-positive, and HIV-unexposed uninfected children aged 3-4 years in Kisumu County, Kenya. The study will collect and analyze 1,080 oral swab samples from 360 children to compare the oral microbiome development...
This federal Project Grant award for $331,999 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to determine the causal relationship between poor oral health and heart disease. The primary awardee, Lehigh University, will construct polygenic scores using a GWAS-by-subtraction genomic structural equation model to identify genetic risk factors for poor oral health. They will then leverage this to...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will fund research to define oral squamous cell carcinoma (OSCC)-associated microbiome and metabolome signatures and determine if microbiota transfer from OSCC patients to mouse models promotes tumorigenesis. The $234,000 award to the University of Colorado-Denver will extend previous studies on the role of the human...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under CFDA program 93.121 Oral Diseases and Disorders Research, provides $409,403 to Branchpoint Biosciences Inc. for the development of a comprehensive qPCR-based oral microbiome profiling platform. The objectives are to: (1) determine key oral microbial targets by analyzing public metagenomic data, and (2) design and validate qPCR assays to accurately detect and quantify those targets....