Project Grant R03AG088969
Award Date
9/1/24
Completion Date
8/31/26
Dollars Obligated
$308K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Salt Lake City, UT 84112, USA
Similar Awards
This $834,094 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to advance research on post-stroke cognitive impairment and dementia (PSCID). The funding will support a multi-year effort leveraging a national stroke registry and Medicare data to determine the incidence and prevalence of PSCID, identify associated risk factors, and explore potential pharmacological prevention strategies. Key aspects of the research include a patient-centered approach,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $663,000 to the University of Texas Health Science Center at Houston to conduct research on the role of cellular senescence in driving sex-specific outcomes of small vessel disease and post-stroke cognitive impairment. The research aims to understand the chronic neurological consequences of small vessel disease following stroke, and evaluate whether delayed treatment strategies targeting the...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $640,906 to the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The project aims to utilize advanced neuroimaging techniques to characterize the impact of vascular disease processes, including vascular stiffness and decreased flow tone, on brain tissue integrity and cognition in the presence...
This $1,521,356 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a study to examine cerebrovascular reactivity (CVR) as a biomarker for vascular contributions to cognitive impairment and dementia (VCID) in patients with the rare genetic condition CADASIL. The University of Wisconsin-Madison is the prime awardee, with sub-awards to the Johns Hopkins University, University of Maryland-Baltimore, and Butler Hospital. The study will leverage a...
This $399,345 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate novel therapeutic strategies for improving outcomes of acute ischemic stroke (AIS) in older mice. The key research objectives are to: (1) Rejuvenate age-associated reductions in endothelial cell (EC) autophagy and restore EC glucose transporter 1 (GLUT1) expression to improve EC function and AIS outcomes; and (2) Evaluate whether the approved drug bryostatin-1 can...
This Federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $146,922 will support a study to evaluate the relationship between life-space and long-term cognitive decline after stroke. The key objectives are to: (1) estimate the effects of life-space components on cognitive decline following stroke in a large observational cohort, (2) characterize the life-space of stroke survivors using geolocation data, and (3) prospectively evaluate the effect of...
This federal Project Grant award of $752,589.00 from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research aims to study the relationship between pathologies in peripheral nerves and the brain, as well as the impact of brainstem pathology and synapse loss, in individuals who died with Alzheimer's disease or related dementias. The award to the University of Iowa, a major public research university, will fund a 5-year research project starting on January 1, 2025 to address the...
This $454,225 Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) will support research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop new methods for assessing "effective reserve" in patients with acute ischemic stroke. The key objectives are to: 1) investigate the concept of effective reserve and its feasibility in acute ischemic stroke patients using two large...
The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,387,438 under the Aging Research program (CFDA 93.866) to The Ohio State University Office of Sponsored Programs on September 19, 2022. The three-year project grant aims to develop and test a novel neuroprotective agent, TAT-M2NX, to provide both acute and sustained synaptic protection following acute ischemic stroke. The research seeks to characterize the agent's...
This $1,919,387 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to assess the impact of reduced cerebral blood flow and neurovascular coupling on brain function and homeostasis in aging. The project aims to use a novel computational homeostatic modeling (HOMOD) approach to calculate regional brain tissue and capillary blood levels of CO2, O2, and pH in young and elderly subjects. The research will utilize calibrated fMRI and fMRS...