Lifespace mobility and cognitive decline after stroke
Ended Project Grant Awarded Last action
- Award ID
- F31AG090102
- Recipient
-
The Leland Stanford Junior University UEI HJD6G4D6TJY5
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $138,088
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date
- Place of performance
- Palo Alto, CA 94305, USA
Award details come from USAspending.gov.
Description
- Abstract
- Stroke is the third leading cause of disability globally, and the number of incident strokes is expected to increase substantially as the size of the population aged 65 and older grows. After a stroke, some patients experience an accelerated decline in cognitive and functional ability, while disability stabilizes for other patients. However, little is known about why cognitive trajectories vary widely after stroke. One theory of cognitive aging is that a more complex living environment is potentially protective against cognitive decline by allowing for opportunities for exercise, recreation, and social activities. One way to measure individuals' living environments is through studying their life-space, which is the size and pattern of the physical area in which they spend their time. Studies have found that life-space is associated with better cognitive function in older adults. However, there is a lack of research in identifying the mechanisms by which life-space is protective against cognitive decline post-stroke. We will leverage two studies to evaluate the relationship between life- space and long-term cognitive decline after stroke. Here, we propose a study that aims to (1) estimate the effects of components of life-space on cognitive decline in the years following stroke in a large observational cohort from the cardiovascular health study (n=5,888), (2) characterize the life-space of stroke survivors using geolocation data in the strokecog cohort (n=270) and (3) prospectively evaluate the effect of components of life-space on cognitive change after stroke. Our findings will advance our understanding of factors that affect the long-term cognitive trajectory after ischemic stroke. This award will also support the career development of sylvie dobrota LAI, a doctoral student in the department of epidemiology and population health at the stanford school of medicine. Through completing the proposed research, the applicant will pursue training in (1) the epidemiology of aging, (2) clinical issues in stroke patients, (3) geospatial data collection and analysis, and (4) career development. The applicant will be supported by a mentorship team comprising of experts in aging epidemiology, statistics, and neurology. Through this fellowship, the applicant will develop strong methodological skills, gain subject expertise, and become a more independent epidemiologic researcher. The proposed study will provide a strong foundation for the applicant's future academic research career and position her to become a leader in aging research.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | -$8,834 | |
| Amendment | $0 | |
| Amendment | $48,974 | |
| Amendment | $0 | |
| Amendment | $48,974 | |
| Amendment | $48,974 | |
| Original award | $0 |
Quick answers
Who received award F31AG090102?
F31AG090102 was awarded to The Leland Stanford Junior University by National Institute on Aging (National Institutes of Health) on January 22, 2025.
How much is award F31AG090102 worth?
$138,088 has been obligated on F31AG090102.
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