This $454,225 Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) will support research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop new methods for assessing "effective reserve" in patients with acute ischemic stroke. The key objectives are to: 1) investigate the concept of effective reserve and its feasibility in acute ischemic stroke patients using two large retrospective stroke cohorts; 2) develop longitudinal assessment methodologies for effective reserve and how changes in it impact stroke outcomes; and 3) enhance the assessment by incorporating spatial information about the stroke lesion and its impact on the brain's compensatory mechanisms. This translational research aims to create a clinically available biomarker that can enhance real-time stroke prognostication and guide individualized patient care to improve functional outcomes. The award period runs from September 1, 2023 through August 31, 2025.
Generated 7/16/24, 5:36 AM