Project Grant R01AG085602

Award Date 9/30/24
Completion Date 6/30/29
Dollars Obligated $801K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Madison, WI 53706, USA
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This federal Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to define the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The $4,693,249 award, valid from September 17, 2024 to August 31, 2027, will support research to characterize the molecular pathways linking...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports a research initiative led by the Washington University in St. Louis to investigate the molecular mechanisms underlying cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID). The $4,361,625 award, with a project period from September...
The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
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This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,120,805.00 to the University of Illinois to investigate the impact of SARS-CoV-2 infection on the brain's blood vessels and its potential contribution to vascular cognitive impairment and dementia (VCID). The research aims to determine how prior COVID-19 infection...
This federal Project Grant award of $2,398,590.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of brain microvascular dysfunction in cognitive impairment and dementia. The multidisciplinary research team at the University of Colorado-Denver will use a variety of experimental approaches, including animal models, native...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under CFDA Program 93.866 Aging Research, supports research on post-stroke cognitive impairment and dementia. The total funding amount is $834,094, with an award date of September 15, 2024 and an ultimate completion date of July 31, 2029. The key products and services to be delivered under this grant include: Determining the incidence and prevalence of post-stroke cognitive impairment and dementia (PSCID) in...
This federal Cooperative Agreement award from the Food and Drug Administration (FDA) Research program (CFDA 93.103) provides $1,277,294 to the University of Wisconsin System to enroll 180 individuals with the CADASIL gene mutation in a study investigating retinal imaging measures as potential diagnostic, prognostic, and disease monitoring biomarkers for vascular cognitive impairment and dementia. The study, which began on September 5, 2024, will focus on three primary retinal assessments: 1)...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $801,476 to the University of Wisconsin System to study cerebrovascular reactivity as a biomarker for vascular contributions to cognitive impairment and dementia (VCID) in patients with CADASIL, a rare genetic form of stroke and VCID. Over the 5-year period from September 2024 to June 2029, the researchers will leverage an existing longitudinal cohort of 400 CADASIL patients and 100 healthy controls to:

  1. Examine if cerebrovascular reactivity, a measure of microvascular function, is lower in CADASIL patients with varying disease severity compared to controls.
  2. Determine if cerebrovascular reactivity in CADASIL patients is associated with other VCID biomarkers and disease phenotypes.
  3. Characterize the trajectory of cerebrovascular reactivity changes over 18 months in CADASIL patients and controls, and its association with VCID biomarkers.

This research aims to provide critical insights into the pathogenesis of VCID using a rare genetic model, which could inform the development of novel biomarkers and interventions for more common forms of age-related cognitive decline.

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