This federal Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to define the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The $4,693,249 award, valid from September 17, 2024 to August 31, 2027, will support research to characterize the molecular pathways linking...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports a research initiative led by the Washington University in St. Louis to investigate the molecular mechanisms underlying cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID). The $4,361,625 award, with a project period from September...
The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
This Project Grant award, titled "CEREBRAL SMALL VESSEL DISEASE AND DEMENTIA: DEFINING GLOBAL RESILIENCE AND DISRUPTION IN BRAIN NETWORKS", is funded by the National Institute on Aging (CFDA 93.866 - Aging Research). The $136,778 award supports a research program led by Wake Forest University Health Sciences to investigate the impacts of cerebral microbleeds, a manifestation of small vessel disease, on brain networks and cognitive impairment. The specific objectives are to utilize...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,120,805.00 to the University of Illinois to investigate the impact of SARS-CoV-2 infection on the brain's blood vessels and its potential contribution to vascular cognitive impairment and dementia (VCID). The research aims to determine how prior COVID-19 infection...
This federal Project Grant award of $2,398,590.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of brain microvascular dysfunction in cognitive impairment and dementia. The multidisciplinary research team at the University of Colorado-Denver will use a variety of experimental approaches, including animal models, native...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under CFDA Program 93.866 Aging Research, supports research on post-stroke cognitive impairment and dementia. The total funding amount is $834,094, with an award date of September 15, 2024 and an ultimate completion date of July 31, 2029. The key products and services to be delivered under this grant include: Determining the incidence and prevalence of post-stroke cognitive impairment and dementia (PSCID) in...
This federal Cooperative Agreement award from the Food and Drug Administration (FDA) Research program (CFDA 93.103) provides $1,277,294 to the University of Wisconsin System to enroll 180 individuals with the CADASIL gene mutation in a study investigating retinal imaging measures as potential diagnostic, prognostic, and disease monitoring biomarkers for vascular cognitive impairment and dementia. The study, which began on September 5, 2024, will focus on three primary retinal assessments: 1)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year study to develop an integrative computational approach for disentangling the underlying pathophysiology of age-related white matter hyperintensities (WMH). The $1,604,034 award, effective September 1, 2024, will leverage existing neuroimaging and genetic data from 7 cohorts and the UK Biobank to derive distinct, disease-specific WMH spatial patterns using machine learning. The...
This National Institute on Aging federal project grant award (CFDA 93.866 - Aging Research) supports research to investigate the impact of neurovascular calcification on brain parenchymal injury and cognitive impairment, particularly in the context of aging and chronic kidney disease. The $181,027 project, running from May 2024 to April 2026, involves a collaborative team analyzing autopsy brain samples from aged chronic kidney disease subjects to determine the relationship between neurovascular...