This federal Project Grant award of $218,261, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research at the University of Virginia to investigate the molecular mechanisms connecting obesity to Alzheimer's disease. Specifically, the two-year project aims to: 1) genetically identify the pathways through which obesity activates the MOAG-4 protein in neuronal cells, and 2) determine how MOAG-4-mediated processes contribute to the neurological...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $372,400.00 to Nova Southeastern University to evaluate the therapeutic potential of three drug compounds - tirzepatide, retatrutide, and crocetin - in mitigating Alzheimer's-like pathology in a mouse model with comorbid obesity and prediabetes. The research aims to elucidate the efficacy of these interventions in improving cognitive-behavioral function, neuropathological changes, and...
This $2,119,771 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) will fund research at the University of Massachusetts Medical School (UMass Medical) to investigate the role of peripheral insulin resistance and inflammation in Alzheimer's disease (AD) pathogenesis. The project aims to define age-related changes in metabolism and inflammation in peripheral organs, particularly the liver, and examine how these processes impact AD-relevant...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $630,905 to the University of Wisconsin - Madison to explore the role of the gut microbiome-derived metabolite imidazole propionate (IMP) in the progression of Alzheimer's disease (AD) and related dementias (ADRD). The research will characterize the relationship between IMP, disruption of the blood-brain barrier, and AD pathology in mouse models, as well as evaluate associations...
The National Institute on Aging has awarded a $1,473,241 Project Grant (CFDA 93.866) to Mayo Clinic to investigate the role of adipose senescent cells in cognitive function and Alzheimer's disease progression. The 5-year grant, awarded on August 15, 2024, will support research aimed at determining whether the accumulation of senescent cells in adipose tissue contributes to cognitive decline and neurodegeneration through endocrine effects. The project will utilize a novel mouse model to deplete...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate neurovascular and lymphatic abnormalities in the brain that may contribute to obesity-linked cognitive impairment. The $801,348 award to The Johns Hopkins University will span 5 years, from June 2025 to February 2030. The project aims to use advanced magnetic resonance imaging (MRI) techniques to assess changes in cerebral blood vessels, perivascular spaces,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,241,676 to The University of Iowa to investigate the role of glycolysis, a key glucose metabolism process, in rodent models of Alzheimer's disease. The project aims to interrogate how disruptions in glycolysis affect neurodegeneration in Alzheimer's disease models, and whether enhancing glycolysis can mitigate neurodegeneration. The research will utilize advanced imaging techniques,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $405,849 to the Keck Graduate Institute of Applied Life Sciences to conduct research on the impact of obesity-induced hepatic amyloid beta dysregulation on Alzheimer's disease pathology. The 2-year project aims to examine how obesity-induced changes in liver function, specifically the overexpression of amyloid precursor protein and downregulation of the lipoprotein receptor-related...
This $125,896 Project Grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a research project led by The Washington University in St. Louis. The project aims to utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and Alzheimer's disease (AD) human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience pathways across genetic, epigenomic,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $112,875 to the University of Wisconsin-Madison to investigate the role of dietary protein in aging and Alzheimer's disease. The research aims to define the metabolic and molecular interactions between dietary protein, the life-extending drug rapamycin, and animal models of early and late-onset Alzheimer's. Specifically, the project will focus on understanding how protein restriction and...