Project Grant R21AG089348

Award Date 9/1/24
Completion Date 5/31/26
Dollars Obligated $631K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
Similar Awards
The National Institute on Aging (NIA) awarded a $502,045 Project Grant (CFDA 93.866 - Aging Research) to the University of Wisconsin-Madison to test the safety and feasibility of a custom probiotic intervention among people with Alzheimer's disease (AD) dementia and preclinical AD. The study aims to evaluate secondary outcomes, such as cognitive function and plasma biomarkers, and explore potential mechanisms by which gut microbiome modulation may impact the brain in AD. The research will be...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to the University of South Florida will support research to determine the role of gut-derived microRNAs (miRNAs) in age-related cognitive decline and Alzheimer's disease and related dementias (ADRD). The $849,904 award, effective September 30, 2024 through August 31, 2026, will fund studies to identify unique miRNA signatures in the blood of older adults with mild cognitive impairment (MCI) and dementia...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
This $825,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the Massachusetts General Hospital to investigate the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. The research will leverage data from the REGARDS and CARDIA longitudinal cohort studies to examine associations between gut microbiome metabolites, brain imaging markers, and the...
This $1,102,206 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project titled "CRCNS: Repurposing Transformers to Characterize Gut Microbiome & Aging Brain Axis" at the University of Wisconsin - Madison. The project aims to design specialized transformer-based machine learning models to analyze associations between gut microbiome composition and brain health in Alzheimer's disease and other dementias. Key objectives...
The National Institute on Aging (NIA) awarded a $856,580 Project Grant (CFDA 93.866 - Aging Research) to the University of Massachusetts Lowell to elucidate the microbial origins of Alzheimer's disease and related dementias (AD/ADRD) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. The project will generate longitudinal gut microbiome and serum metabolomic profiles for approximately 2,800 HCHS/SOL participants to investigate the role of the gut microbiome in AD/ADRD...
The University of Alabama at Birmingham (UAB) has been awarded a $1,869,019 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a 3-year research project to investigate the role of circadian rhythms, gut microbiome, and gut-to-brain signaling in the onset and progression of Alzheimer's disease (AD) using a Drosophila (fruit fly) model. Key objectives include determining whether depletion of gut microbiota...
The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the role of microglia, the brain's immune cells, in the development of Alzheimer's disease (AD). The University of Washington (UW) will leverage novel explainable AI techniques and human induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes that occur early in AD progression. Specifically, UW will expose microglia-neuron iPSC cultures to...
This Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $1,189,692 to Bloom Science, Inc. to develop neuroprotective engineered bacteria for treating Alzheimer's disease. The project aims to select and engineer the probiotic bacterium Akkermansia muciniphila to produce anti-inflammatory compounds like butyrate, beta-hydroxybutyrate, and ursodeoxycholic acid, with the goal of reducing neuroinflammation and disease progression...

This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $630,905 to the University of Wisconsin-Madison to explore the role of the gut microbiome-derived metabolite imidazole propionate (IMP) in the progression of Alzheimer's disease (AD) and related dementias (ADRD). The central hypothesis is that IMP modulates AD and ADRD pathology by altering vascular endothelial function and blood-brain barrier permeability. The research will characterize the relationship between IMP, blood-brain barrier disruption, and AD pathology in mouse models, and leverage existing data from the Wisconsin Alzheimer's Disease Research Center to examine IMP's association with fluid biomarkers and vascular injury. This effort aims to elucidate how the gut microbiome can shape AD/ADRD through its effects on vascular function, representing a novel perspective that could inform future preventative and therapeutic interventions. The award period runs from Sep 1, 2024 to May 31, 2026.

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