Project Grant R03AG088813

Award Date 6/1/25
Completion Date 5/31/26
Dollars Obligated $311K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $372,400.00 to Nova Southeastern University to evaluate the therapeutic potential of three drug compounds - tirzepatide, retatrutide, and crocetin - in mitigating Alzheimer's-like pathology in a mouse model with comorbid obesity and prediabetes. The research aims to elucidate the efficacy of these interventions in improving cognitive-behavioral function, neuropathological changes, and...
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The key objectives are to: 1) rigorously test the ability of sleeve gastrectomy to prevent metabolic disease, age-related frailty, and AD pathology in two mouse models of AD; 2) perform comprehensive metabolic and cognitive phenotyping and correlate these findings with markers of AD; and 3) use spatial transcriptomics and single-nucleus RNA sequencing to elucidate the mechanisms by which bariatric surgery impacts AD pathogenesis. The research aims to enhance the mechanistic understanding of how metabolic interventions can influence brain health and identify novel targets for future AD treatments. The award period runs from June 1, 2025 to May 31, 2026.

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