This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to elucidate the role of RNA modification in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The $745,092 award to the University of Virginia will fund a 5-year study to: 1) Decode the epitranscriptomic (RNA modification) profiles impacted by tau pathology in AD; 2) Determine the role of RNA methylation in AD pathogenesis using 3D neuron-glial brain assembloids;...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) in the amount of $644,000 supports research to investigate the role of RNA methylation dysregulation in the metabolism of amyloid-beta (Aβ) and its contribution to Alzheimer's disease pathology. The research will determine the effect of reduced METTL3-mediated N6-methyladenosine (m6A) modification on mRNA metabolism, including mRNA decay, translation, splicing, and nuclear export,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,156,262.00 to Case Western Reserve University's Office of Research Administration Division (doing business as University Hospitals of Cleveland) to conduct research on the role of N6-methyladenosine (m6A) RNA modification dysregulation in the pathogenesis of Alzheimer's disease. The research aims to determine how reduced expression of the m6A methyltransferase enzyme METTL3...
This federal Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $816,661 to The Regents of the University of California, San Francisco to conduct research on the molecular and cellular mechanisms by which pathological tau protein drives neurodegeneration in Alzheimer's disease (AD) and related tauopathies. The project will leverage expertise in mass spectrometry-based proteomics and functional genomics to comprehensively map the impact of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $419,375.00 to the University of Florida to investigate the role of the tau-RNA interaction in neurodegenerative diseases, particularly Alzheimer's disease. The award will fund research to identify specific RNA motifs that may either enhance or inhibit the development of tau protein condensates and pathology. The goal is to better understand the mechanisms by which tau-RNA interactions...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $1,118,700.00 will fund research by New York University School of Medicine to investigate the role of pathological tau protein in disrupting the endosomal microautophagy (EMI) pathway. The proposed experiments aim to elucidate how tau pathology leads to impairment of the EMI pathway, which is crucial for protein quality control and neuronal function. The research will manipulate key...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in neurodegenerative diseases like Alzheimer's. The central hypothesis is that pathogenic forms of tau represent misregulation of normal tau functions as a scaffold for signaling pathways. The 2-year project aims to define the effects of tau post-translational modifications on tau function and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $763,922 supports research into the shared mechanisms of tau toxicity among neurodegenerative diseases. The primary awardee, The Leland Stanford Junior University, will use in vivo animal models and human iPSC-derived cell culture models to investigate how tau-induced regulation of reverse electron transport in mitochondrial complex I contributes to the development of Alzheimer's disease,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Texas Health Science Center at Houston provides $429,000 in funding from June 1, 2025 to May 31, 2026 to investigate the role of metal regulatory transcription factor-1 (MTF-1) in neurodegenerative diseases such as Alzheimer's, tauopathies, and Lewy body dementia. The research aims to determine if aberrant MTF-1 activation is necessary and sufficient to drive neurodegeneration in fly...
This $784,596 Project Grant award, made under the National Institute on Aging's Aging Research program (CFDA 93.866), supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models at Northeastern University. The project aims to develop a state-of-the-art proteogenomic pipeline to globally profile disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic...