This is a Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) to the University of South Florida for $150,000 over the period of September 1, 2024 to June 30, 2026. The project aims to identify enhancer RNAs (eRNAs) and enhancer-gene regulatory networks that are activated in response to hippocampal hypoperfusion and the development of vascular dementia in a mouse model. The research will use unbiased, genome-wide approaches including ChIP-seq, RNA-seq, and Hi-C to map active enhancers, their associated eRNAs, and enhancer-promoter interactions across the progression of vascular dementia. This work will generate a catalog of key regulatory elements and networks involved in the pathophysiology of vascular dementia, laying the foundation for future mechanistic studies on their functional impact.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $150.0k | 8/16/24 |