Project Grant R01NS148641
- Federal Project Grant Award Summary The University of South Florida received a $739,646 Project Grant awarded June 9, 2025, by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant supports research investigating the role of SARS-CoV-2-induced cellular senescence in Alzheimer's disease development, with research to be conducted in Tampa, Florida, through March 31,...
- Federal Project Grant Award Summary Colorado State University received a $2,674,385 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded August 15, 2025, with completion targeted for July 31, 2029. This research initiative investigates structure-function relationships in alpha-synuclein protein strains using cryo-electron microscopy (cryo-EM)...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $460,625 to the University of Massachusetts Medical School on June 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This exploratory research project, scheduled for completion by May 31, 2027, investigates the roles of the deubiquitylation pathway in TDP-43 (TAR DNA-binding protein 43) pathology relevant to...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,766,366 to Harvard T.H. Chan School of Public Health, with an award date of May 6, 2026 and completion date of April 30, 2029. Under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), the awardee will conduct research investigating the impact of environmental factors on Lewy Body Dementia (LBD), a neurodegenerative...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant of $423,500 on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This two-year award, with completion scheduled for July 31, 2027, funds research investigating the mechanisms underlying cognitive dysfunction in neuromyelitis optica (NMO), a central nervous...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc., through its Department of Faulkner Pathology in Boston, Massachusetts, received a $557,883 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award was obligated on May 1, 2026, with a completion date of April 30, 2031. This five-year research initiative investigates the...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Broad Institute of MIT and Harvard a $481,250 Project Grant on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports a two-year research initiative concluding July 31, 2027, focused on advancing prion disease treatment through deep prion protein (PrP) suppression. The project will deliver...
- Federal Grant Award Summary Baylor College of Medicine received a $3.04 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of July 31, 2029. The grant funds research investigating the relationship between SARS-CoV-2 (COVID-19) infection and the initiation and acceleration of Alzheimer's disease (AD) and related dementias (AD/RD), including Pick's disease, frontotemporal dementia, and...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $2,813,759 in Project Grant funding (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of Nevada, Reno, effective August 15, 2025, through July 31, 2029. This award supports fundamental neuroscience research investigating the relationship between the locus coeruleus-norepinephrine network and neurovascular coupling in health...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded Louisiana State University Health Sciences Center-Shreveport a $401,500 Project Grant on June 17, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate SARS-CoV-2 tropism and immunomodulation in salivary gland tissue. The two-year research project, scheduled for completion by June 16, 2027, will deliver fundamental scientific research examining how SARS-CoV-2...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Louisiana State University Health Sciences Center-Shreveport $582,172 on May 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This Project Grant funds a mechanistic investigation into the chronic neuropathologic interaction between viral infection and the progression of Lewy pathology and dementia. The research will utilize a human ACE2 (angiotensin-converting enzyme 2) transgenic mouse model to examine how SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection may trigger alpha-synucleinopathies and contribute to post-acute sequelae of COVID-19 (PASC) and age-dependent neurological decline. The study addresses the documented phenomenon of Lewy pathology in Long-COVID patients and seeks to elucidate shared molecular and cellular mechanisms between viral infection and Alzheimer's Disease and Related Dementias (ADRD), with particular focus on dementia with Lewy bodies (DLB), the second most common form of dementia. The research will generate fundamental knowledge regarding genotoxic stress, autophagy-lysosome dysfunction, and synucleinopathy pathogenesis through in vivo investigation. Deliverables will include scientific findings on the pathogenic role of viral infection in neurodegeneration, potentially informing therapeutic approaches for synucleinopathies and post-COVID neurological complications. The project timeline extends from the May 2026 award date through April 30, 2030, conducted at the awardee's Shreveport, Louisiana facility in BSL-3 (biosafety level 3) compliance.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $582.2k | 5/14/26 |