Project Grant R01NS148342
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UCLA a $2.22 million Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025, through July 31, 2029. This award supports preparation for a community-engaged clinical trial of a patient navigation intervention designed to improve equitable access to neurology care and emerging Alzheimer's Disease and...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UCLA a $460,563 Project Grant effective August 1, 2025, through July 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award supports research and development activities focused on translating ProSAAS (Progranulin-derived Secreted Protein Associated with Synapses), a brain-specific cellular chaperone, into a therapeutic...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $446,991 to the University of California, Los Angeles under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 7, 2025, with completion scheduled for July 31, 2027. This Project Grant supports the development of a novel diagnostic assay for identifying parkinsonian tauopathies, specifically progressive supranuclear palsy...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $196,875 to the University of California, Los Angeles under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) effective June 1, 2026 through May 31, 2028. This Project Grant funds a comprehensive biomarker discovery and evaluation initiative focused on identifying blood-based biomarkers for genetic ataxias, a class of rare...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded University of California, Los Angeles $407,739 on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This two-year project grant, extending through July 31, 2027, supports basic neuroscience research investigating the regulation of axon caliber in sensory neurons, with particular focus on the role of...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2.06 million Project Grant (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Regents of the University of California, San Francisco on July 19, 2025, for research extending through March 31, 2030. The award funds quantitative diffusion magnetic resonance imaging (MRI) analysis to improve prognostic characterization of neonatal...
- Federal Project Grant Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3.11 million Project Grant to the University of California, Los Angeles (UCLA) Office of Research Administration, effective August 1, 2025 through July 31, 2029, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This grant supports the development and validation of human induced pluripotent stem cell (iPSC)-derived hippocampal...
- Federal Project Grant Award Summary The University of California, San Diego received a $129,186 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded July 15, 2026, with completion scheduled for January 31, 2028. The award funds basic neuroscience research investigating the relationship between mitochondrial DNA (mtDNA) integrity and neuronal...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UCLA a Project Grant totaling $551,250 on June 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research focuses on understanding the molecular basis of synaptic specificity in the Drosophila melanogaster visual system. The project will investigate how neurons form precise synaptic connections through cell...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded J. David Gladstone Institutes a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 1, 2025, through August 31, 2033. This eight-year award supports multidisciplinary research investigating neurovascular dysfunction and its role in neurodegeneration, central nervous system (CNS)...
UCLA received a $653,072 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 15, 2026 through May 31, 2031. The award supports the development and delivery of a comprehensive, multimodal magnetic resonance imaging (MRI)-based analytical framework for mapping spatiotemporal changes in Huntington's disease (HD) progression. The research integrates multiple advanced imaging modalities—including structural and diffusion MRI, resting-state functional MRI (fMRI), quantitative susceptibility mapping (QSM), and spectroscopy-based metabolic imaging—to characterize alterations in brain atrophy, microstructural integrity, iron deposition, myelin content, and striatal metabolism across the disease spectrum in both premanifest and symptomatic HD individuals. The project focuses on analyzing key neural circuits (cortico-striato-thalamo-cortical and cerebello-thalamo-cortical pathways) using publicly available HD datasets and prospectively acquired multi-center 3-Tesla MRI data to identify regional and tract-based structural, functional, and metabolic biomarkers. These research deliverables are intended to establish sensitive and specific biomarkers for monitoring disease progression in premanifest individuals, thereby supporting the development and evaluation of disease-modifying therapies for Huntington's disease.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $653.1k | 6/11/26 |