Project Grant R01NS146078
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is supporting research to develop a highly optimized two-photon (2P) multiplexing system for enabling high-fidelity, large-scale voltage imaging of neuronal activity in vivo. The $768,000 grant, awarded on September 20, 2025, aims to address the technical challenges of current voltage imaging techniques, which have been limited to small neuron...
- This federal Project Grant award of $578,701, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop a new high-speed 3D voltage imaging microscopy system capable of capturing real-time neuronal activity over extended periods. The research, conducted by the University of California, Los Angeles (UCLA), aims to overcome the limitations...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will fund the development and validation of a family of genetically encoded, fluorescent "chemogenetic" voltage sensors for in vivo brain imaging. The 3-year, $2,329,605 grant to Brown University aims to create improved far-red and two-photon compatible...
- This $556,525 Project Grant was awarded on June 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant will fund the development, testing, and dissemination of micro-LED optoelectrode platforms for monitoring and perturbing targeted neurons in multiple local brain circuits. These platforms will provide a new tool for analyzing the dynamic...
- The Project Grant award of $535,416 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports the development of a technological toolkit for noninvasive mapping of ionic activity in the mouse brain. The goal is to create a voltage-sensing nanoprobe using DNA nanoparticles, indocyanine green dye, and a quencher, which can provide high-resolution...
- This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $434,716 to the University of Oklahoma Health Sciences Center to develop a set of optical tools for capturing and interpreting high-speed recordings of neural activity across the entire zebrafish brain. The key objectives are to create fluorescent voltage sensors, optical microscopes, and signal processing algorithms that can simultaneously monitor millisecond-scale bursts of neural...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,724,344 Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to the Massachusetts Institute of Technology (MIT). The grant, awarded on August 1, 2025, supports the development of two new high-speed image sensor technologies: A 600 x 800 pixel sensor with 1 kHz temporal resolution for fluorescence micro-endoscopy in freely moving mice. A 600...
- This $632,776 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) aims to fundamentally advance the understanding of astrocyte physiology. The grant supports research at Baylor College of Medicine to use novel genetically encoded voltage indicators (GEVIs) to measure astrocyte membrane potential and local neural activity in the mouse visual...
- This $1,344,223 Project Grant awarded by the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding research to develop a novel nanomaterial-based platform for noninvasive neuroengineering. The key objectives are to: Engineer ultra-bright upconversion nanoparticles that can convert near-infrared light into visible light for deep brain optogenetic stimulation. Leverage focused ultrasound to deliver the nanoparticles across the...
This Project Grant award of $621,065 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development of advanced genetically encoded voltage indicators (GEVIs) optimized for two-photon microscopy. The goal is to create GEVIs with improved sensitivity for detecting subthreshold signals and enhanced response kinetics to reliably capture rapid action potentials in awake, behaving animals. Key innovations include refining high-throughput screening to identify fast-kinetics GEVI variants, engineering ultrasensitive GEVIs tailored for synaptic activity, and designing advanced subcellular targeting strategies to minimize background fluorescence. The optimized GEVIs will undergo rigorous validation in vitro and in vivo, combining electrophysiology and two-photon microscopy to benchmark their performance against existing tools. This project aims to expand the utility of voltage imaging and provide neuroscience researchers with powerful tools to explore brain function.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $621.1k | 7/28/25 |