This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $398,342 to the University of California, Davis to develop a novel miniature two-photon microscope that can simultaneously perform calcium imaging and optogenetic manipulation of neural activity in freely behaving mice. The device will integrate advanced optical and...
This Project Grant award of $348,373 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a novel family of biosensors that can be used to report on and dynamically regulate changes in neuroinflammation within the brains of live animals. The key products and services to be delivered through this grant include: 1) Developing and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will fund the development and validation of a family of genetically encoded, fluorescent "chemogenetic" voltage sensors for in vivo brain imaging. The 3-year, $2,329,605 grant to Brown University aims to create improved far-red and two-photon compatible...
The National Institute of Neurological Disorders and Stroke (NINDS), through its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $578,701 project grant to the University of California, Los Angeles (UCLA) on June 16, 2025. The goal of this 5-year project is to develop a near-infrared confocal squeezed light-field microscopy (SLIM) system capable of kilohertz volumetric imaging of neuronal action potentials in 3D. This technology is intended to...
This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,360,447.52 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop and evaluate an inexpensive, lightweight "brain monitor" device using magnetic resonance imaging (MRI) technology. The goal is to create a portable MRI-based...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $388,158.00 to the University of California, Los Angeles (UCLA) to engineer a highly active and selective gamma-Aminobutyric Acid (GABA) oxidase enzyme. The goal is to develop a high-performance, implantable, electroenzymatic GABA microsensor that can monitor GABA transients in the...