This $337,422 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to develop a novel "neuron-to-neuron interface" that can transmit signals between individual neurons in the brains of two zebrafish larvae. The researchers at the University of Illinois seek to create a system that allows synchronized behavioral outputs in both a "sender" and "receiver" fish by transmitting neural signals optically between their...
This $600,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at the University of Illinois at Chicago to address challenges in damaged neuron circuits by reprogramming the brain. The project aims to develop a new method to manipulate neural circuit development by transferring and replicating neural signals from one brain to another using zebrafish larvae as a model system. The long-term goal is to reconstruct maladaptive...
This National Science Foundation project grant award of $299,323 provides funding for research services at the University of Oklahoma from April 15, 2022 through March 31, 2024. The award is made through the Integrative Activities program (CFDA 47.083), which supports activities to build STEM capacity and broaden participation in research. Specifically, the award will fund the development of a novel mesoscopic imaging technique to investigate functional neuronal connections in the mouse...
This $424,750 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports the development of an ultrashort-pulse optical neural network system for brain-scale computing. The research aims to leverage the speed, bandwidth, and low-loss properties of light to enable real-time processing of billion-scale neural network models using minimal spatial elements. This approach seeks to overcome the limitations of current optical computing architectures. The...
This Project Grant award of $420,334 from the National Science Foundation's Engineering program (CFDA 47.041) will support the development of novel microcoaxial electro-optical probes for minimally invasive interfacing with spinal neural circuits. The probes will be small, flexible, and able to simultaneously record electrophysiological activity and optically stimulate neurons in the spinal cord. The project aims to advance the engineering of high-density, multi-modal probe arrays that can be...
This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports the development of a new optical microscopy technology called "Space-Time-Pulsed Engineered-Excitation for Diffraction-Free Imaging (SPEEDI)." The technology utilizes exotic space-time wave packets to enable high-resolution fluorescence imaging of deep brain tissue without the light scrambling issues of conventional microscopy. The research aims to advance imaging...
This $423,626 Project Grant, awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program, supports a research project at Montclair State University to investigate the neurobiology of cognition and emotion in teleost (bony) fish. The key objectives are to: 1) Refine a behavioral paradigm to study associative emotional learning in zebrafish and visualize the functional connectivity of activated neurons in the amygdala and forebrain; and 2) Implement spatial...
This Project Grant award from the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) will provide $432,452 to New York University (NYU) from May 1, 2025 to April 30, 2030 to develop innovative wireless systems for high-resolution neural recording and brain-machine interface applications. The key objectives are to advance wireless power transmission, increase communication bandwidth, and scale up high-channel-count neural electrode arrays. This will involve creating...
This Project Grant awarded by the National Science Foundation (CFDA 47.041 - Engineering) to the University of Illinois will fund the development of a new "Super-Resolution PAUL (SPAUL)" imaging platform. The $500,000 award, effective March 1, 2025 through February 28, 2030, will enable researchers to capture detailed, real-time images of cerebral blood flow, volume, and oxygenation in animals performing specific tasks. The goal is to provide critical insights into the mechanisms...
This National Science Foundation (NSF) Project Grant award, funded under the Engineering program (CFDA 47.041), aims to establish closed-loop hybrid intelligence (HI) by co-designing high-resolution neuromodulation and neuromorphic devices for application to cultured neurons and organoids. The key products and services to be delivered through this $200,000 award, with a performance period from June 15, 2025 to May 31, 2028, include: Developing optogenetic cell interfaces composed of close-packed...