Project Grant R01MH141913
- The National Institute of Mental Health (NIMH) awarded a $314,113 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Physical Sciences Inc. (PSI) of Andover, MA. The grant will fund the development and demonstration of a high-speed, multicolor confocal fluorescence imager to simultaneously capture multi-wavelength signals and display them as separated or merged multicolor images and 3-D stacks. This technology innovation will enable mapping of complex neuronal network...
- The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
- This Project Grant award of $621,065 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development of advanced genetically encoded voltage indicators (GEVIs) optimized for two-photon microscopy. The goal is to create GEVIs with improved sensitivity for detecting subthreshold signals and enhanced response kinetics to reliably capture rapid action potentials...
- This federal Project Grant award of $578,701, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop a new high-speed 3D voltage imaging microscopy system capable of capturing real-time neuronal activity over extended periods. The research, conducted by the University of California, Los Angeles (UCLA), aims to overcome the limitations...
- This $1,344,223 Project Grant awarded by the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding research to develop a novel nanomaterial-based platform for noninvasive neuroengineering. The key objectives are to: Engineer ultra-bright upconversion nanoparticles that can convert near-infrared light into visible light for deep brain optogenetic stimulation. Leverage focused ultrasound to deliver the nanoparticles across the...
- Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...
- This Project Grant award of $517,546, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to optimize, benchmark, and validate a novel multimodal microelectrode array (MEA) probe that integrates fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrical recording. The research team, led by investigators from Dartmouth College, aims to develop this integrated MEA platform...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $2,565,783 to Oregon Health & Science University (OHSU) from September 1, 2023 to August 31, 2026 to develop novel genetically encoded sensors and actuators for monitoring and manipulating neuromodulatory signaling activities in the brain at the cellular and circuit levels. The project aims to enable large-scale in vivo...
- This Project Grant award, valued at $120,015.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research by the President and Fellows of Harvard College to develop a novel technological pipeline that enables the monitoring of large-scale neural activity in freely moving animals and the identification of the transcriptomic identity of the same individual neurons. This research aims to achieve a...
- The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is supporting research to develop a highly optimized two-photon (2P) multiplexing system for enabling high-fidelity, large-scale voltage imaging of neuronal activity in vivo. The $768,000 grant, awarded on September 20, 2025, aims to address the technical challenges of current voltage imaging techniques, which have been limited to small neuron populations or superficial brain regions. The proposed optical platform is designed to deliver improved temporal, spatial, and energy efficiency to meet the requirements of genetically encoded voltage indicators (GEVIs) for simultaneously monitoring activity in large neuronal populations with single-cell resolution. This research has the potential to drive the iterative development of enhanced voltage indicators and enable diverse biological applications for understanding brain function and behavior.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $768.0k | 9/18/25 |