Project Grant R01NS144826
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,270,237 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, effective August 1, 2025, will support a program to investigate the pathogenic mechanisms associated with neural disease in Congenital Disorders of Glycosylation (CDG). The program will utilize zebrafish, Drosophila, and human...
- This federal Project Grant award of $364,448.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) focuses on investigating the neural functions of glycoprotein sialylation. The research aims to reveal sialylation-mediated mechanisms of glia-neuron coupling, elucidate the role of sialylation in promoting neuronal viability and resistance to oxidative stress, and characterize...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- This federal Project Grant award, valued at $643,377.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate cellular mechanisms of enteric nervous system damage in CLN2 disease, a rare neurodegenerative lysosomal storage disorder. The research aims to better understand how lysosomal dysfunction leads to...
- This federal Project Grant award, valued at $147,486, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of this award is to investigate the function of a ciliary protein in neural development, with a focus on uncovering novel molecular mechanisms involved in synapse formation that may be relevant to neurological disorders. Using C. elegans as...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This $614,009 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research into the molecular mechanisms of oligodendrocyte myelination and remyelination, which are critical processes for addressing demyelinating diseases of the central nervous system like multiple sclerosis. The awardee, Children's Hospital...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $442,750 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Case Western Reserve University. The funding supports research to investigate the role of the CCPG1 protein, an endoplasmic reticulum (ER)-phagy receptor, in maintaining the proteostasis of gamma-aminobutyric acid type A (GABAA) receptors in the central nervous system. The research aims to...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $576,841.00 to The Trustees of the University of Pennsylvania to conduct research on "Mechanisms of DCC Receptor Signaling in Neuronal Morphogenesis". The research aims to define how the DCC receptor protein coordinates signaling pathways that regulate the...
The federal Project Grant award of $719,498 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) supports research at The Children's Hospital of Philadelphia Research Institute to elucidate the neurobiological functions of glycosylation and its role in congenital disorders of glycosylation (CDG). The research aims to identify the neurological impacts of disrupted O-glycosylation in CDG using mouse models and human cells/organoids, with the goal of understanding the pathophysiology of CDG and other neurological diseases to enable therapeutic advances targeting glycosylation pathways. The award has an effective date of August 1, 2025 and a projected completion date of July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $719.5k | 7/31/25 |