Project Grant R01NS143143

Award Date 12/5/24
Completion Date 11/30/27
Dollars Obligated $374K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Stony Brook, NY 11794, USA
Similar Awards
This Project Grant award, totaling $2,130,388.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award aims to improve understanding of why some stroke patients have poor outcomes despite successful recanalization (reopening of blocked blood vessels). The key products and services to be delivered include: Developing a longitudinal...
This $770,502 project grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to understand the molecular mechanisms underlying cerebral small vessel disease (CSVD) and its relationship to vascular contributions to cognitive impairment and dementia (VCID). The research will utilize mouse models with COL4A1 and COL4A2 gene mutations, which are...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Neuroscope Inc. in the amount of $1,193,370 aims to develop a computational toolset for mapping and quantifying perivascular space (PVS) morphology from MRI. The goal is to create a non-invasive, automated method to assess PVS, which is an important diagnostic feature for Alzheimer's disease and vascular dementia. The funded work will build the IT infrastructure to commercialize Neuroscope's PVS...
This $538,523 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of an innovative imaging and computational platform for integrated analysis of biodata. The platform aims to enable rapid and unbiased analysis of entire organs at subcellular resolution, with a focus on studying glial cell development in the mouse forebrain. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $4,361,625 to The Washington University to investigate the pathogenesis of cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID). The key objectives are to: Identify cerebrospinal fluid proteins and metabolites related to different white...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $776,503 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of perivascular inflammation and vascular remodeling in cerebral small vessel diseases (CSVD), which can lead to intracerebral hemorrhage. The project will leverage autopsy cases and mouse...
This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Research Foundation For The State University Of New York, doing business as Stony Brook University. The 5-year, $537,508 grant, awarded on December 1, 2024, supports research to investigate the role of endogenously formed zinc protoporphyrin (ZnPP) in intracerebral hemorrhage...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $433,159 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Maryland, Baltimore. The grant, effective August 1, 2024 through June 30, 2029, will fund research to define the precise mechanisms through which calcium-activated chloride channels in brain pericytes contribute to the control of capillary blood flow and how neuronal...

This Project Grant award of $373,778 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a novel vasculature database and analytical platform for studying mouse brain vasculature. The project aims to establish topology-preserving vessel segmentation methods and advanced topological features, mappings, and visual analytic tools to analyze brain vasculature. This research is expected to provide fundamental anatomical support for further physiological and pathophysiological studies in understanding disorders such as Alzheimer's disease and stroke. The award was made to The Research Foundation For The State University Of New York, doing business as Stony Brook University, and will run from December 5, 2024 to November 30, 2027.

Generated 7/8/25, 1:13 PM