This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $621,500.00 to develop new methods for combined molecular and ultrastructural imaging of neural cells and tissues. The key objectives are to: Develop detergent-free multicolor immunoprobes using single chain variable antibody fragments (scFvs) to enable correlative light...
The University of North Dakota was awarded a $419,038 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant, which runs from September 17, 2024 to August 31, 2027, will fund the development of a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging in freely behaving mice. This...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $235,887 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Stony Brook University. The grant supports research to develop a chemical strategy for imaging synapses and neural circuit connectivity in post-mortem specimens, including potentially the human brain. The approach aims to enable direct visualization of neural circuitry using light microscopy,...
The National Institutes of Health (NIH) Office of the Director awarded a $1,271,280 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute in Seattle, WA. The award, spanning September 2024 to September 2027, aims to develop two "exa-scale" (extremely high-throughput) tissue readout methods to transform the study of the brain. The first method will enable highly multiplexed molecular mapping of individual proteins across entire brains at the...
This federal Project Grant award of $354,600.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will support the development of novel methodologies for simultaneous, distributed perturbation of multiple cortical regions using patterned light in head-fixed mice. The goal is to infer how large-scale patterns of cortical activity underlie...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $629,031 to the University of Wisconsin-Madison to develop a novel label-free, live-cell classification system for neural stem cell (NSC) activation state. The key objectives are to: 1) identify the molecular signal associated with a key autofluorescence signal that enables...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $578,701 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of California, Los Angeles (UCLA) to develop a near-infrared confocal squeezed light-field microscopy (SLIM) system for kilohertz volumetric imaging of neuronal action potentials. The goal is to overcome limitations of existing 3D optical imaging techniques and enable high-speed,...
This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $621,617 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of North Carolina at Chapel Hill (UNC-CH) for the project "OPTIMIZED HIGH-RESOLUTION FAST MAGNETIC RESONANCE FINGERPRINTING WITH CLOUD-BASED RECONSTRUCTION." The project aims to develop and optimize a rapid and robust quantitative magnetic resonance imaging (MRI) technique...