This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, is focused on developing a noninvasive, nanoparticle-directed therapy to deliver treatments to the peripheral nervous system. The $310,834 award to Clemson University supports research to design and implement a nerve-targeting polymersome platform that can penetrate the blood-nerve barrier and lead to functional recovery after peripheral nerve crush injuries. The project will investigate the use of two targeting ligands, apolipoprotein E and rabies virus glycoprotein peptide RVG-9R, to enhance delivery through the injured blood-nerve barrier. It will also study the nerve regenerative effects of a G3BP1 peptide and siRNA targeting prenyl-CDC42 mRNA, delivered through the polymersome system. The award period runs from July 2025 through March 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $310.8k | 7/4/25 |