This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support the development of a novel synthetic biology platform for inducible and multiplexed gene regulation in neurons. The $193,000 award to The Leland Stanford Junior University (Stanford University) aims to create an innovative CRISPR-based system that can simultaneously activate and repress multiple genes involved in regulating axon regeneration and neuronal repair. The 2-year project will leverage human induced pluripotent stem cell-derived neurons to characterize how these gene interactions influence neural regeneration, with the goal of advancing understanding and potential therapeutic interventions for neurological conditions. This work addresses unmet needs in synthetic neuroscience and provides a unique strategy for studying the complex genetic pathways underlying neuronal repair and regeneration.
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