Project Grant R01NS142297
- Federal Grant Award Summary The University of Missouri System received a $234,750 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective June 1, 2025, through May 31, 2027. The award supports research investigating the mechanisms of cerebral small vessel disease (CSVD) and its contribution to stroke and dementia in aging populations. The research...
- Federal Grant Award Summary The Ohio State University received a $499,452 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, with an award date of May 15, 2025, and completion date of April 30, 2030. This award supports fundamental research investigating the disease mechanisms of Charcot-Marie-Tooth Disease Type 2E (CMT2E) and the development of...
- Federal Grant Award Summary The University of Missouri System received a $418,043 Project Grant from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded August 1, 2025, with completion targeted for July 31, 2027. This award supports the design and development of a self-tunable messenger RNA (mRNA) gene circuit engineered to achieve sustained, precise control...
- Federal Grant Award Summary The University of Missouri System received a $572,715 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 1, 2025, through June 30, 2030. The research project investigates spinal dopamine receptor mechanisms regulating the micturition reflex following spinal cord injury (SCI). The project will deliver...
- Federal Grant Award Summary The University of Missouri System received a $357,666 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded July 1, 2025, with completion targeted for May 31, 2030. This five-year research initiative will advance understanding of DNA-manipulating enzyme dynamics through the development and application of single-molecule biophysical measurement techniques, including...
- The University of Missouri System received a $622,881 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 5, 2025, through July 31, 2030. The award funds research investigating novel mechanisms of metabolic reprogramming in reactive astrocytes and its role in brain repair following focal cerebral ischemia (FCI). The research...
- Federal Grant Award Summary The University of Missouri System received a $384,896 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period July 1, 2025, through April 30, 2030. The award supports research on maximizing peptide therapeutic delivery through biomodulatory materials design. The research will engineer biomaterials with physicochemical properties designed to directly...
- Federal Project Grant Award Summary Albany Medical College received a $562,051 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, awarded March 6, 2026, with a completion date of February 28, 2031. The award supports research investigating the modulation of the Hippo pathway as a novel therapeutic approach for Charcot-Marie-Tooth Disease Type 1A...
- Federal Grant Award Summary The University of Missouri System received a $429,394 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective December 15, 2025, with completion targeted for November 30, 2027. This award funds research investigating LARP6 (LA Ribonucleoprotein 6) as a potential therapeutic target for age-associated heart failure with preserved ejection fraction (HFpEF)—a condition characterized by cardiac fibrosis and...
- Federal Grant Award Summary The University of Missouri System received a $411,454 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through May 31, 2030. This award supports fundamental research focused on controlling drug crystallization, polymorphism, and physicochemical properties using mechanochemistry techniques. The research program investigates the relationship between...
The University of Missouri System received a $574,083 Project Grant award dated March 15, 2026, from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds development of a vector-based therapeutic intervention for Charcot-Marie-Tooth disease type 2E (CMT2E), a prevalent inherited neurological disorder affecting approximately 1 in 2,500 individuals in the United States. Research will be conducted at the University of Missouri's Columbia, Missouri campus through January 31, 2031. The project delivers preclinical research services focused on therapeutic development using a novel mutation-specific animal model. The research team will develop and evaluate a mutation-agnostic vector-based therapeutic approach targeting neurofilament light gene (NEFL) mutations associated with CMT2E. The deliverables include characterization of disease mechanisms using a newly developed NEFL-E397K mouse model that recapitulates human CMT2E pathology, preclinical efficacy testing of the proposed therapeutic vector, and advancement toward potential clinical translation of a precision medicine treatment for this currently incurable neurological disorder.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $574.1k | 3/13/26 |