Project Grant R01NS140664
Award Date
5/15/25
Completion Date
4/30/30
Dollars Obligated
$499K
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Ohio, USA
Similar Awards
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $430,265 Project Grant (CFDA 93.853) to The Jackson Laboratory in Bar Harbor, Maine on July 1, 2024. The grant supports research to develop a gene therapy treatment for Charcot-Marie-Tooth Type 2D (CMT2D), a rare inherited peripheral neuropathy. The key activities include optimizing an adeno-associated virus (AAV) vector to deliver specific tRNA genes that can suppress the neuropathy phenotype in CMT2D mouse models...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $352,073 to support research on using an ABCA1 cholesterol transporter agonist to correct pathophysiological myelin formation in hereditary neuropathies. The research aims to advance a novel candidate drug for restoring functional cholesterol access and supporting myelin...
The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded The Ohio State University a $119,018 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program. This grant will support research into strategies to interrogate and enhance myelin remodeling in distal tissue after spinal cord injury. The goal of the NINDS program is to fund basic and applied research exploring the brain, nervous system structure...
This $713,818 Project Grant awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports research by the Research Institute at Nationwide Children's Hospital in Columbus, Ohio to characterize novel patient-specific modeling systems for NF2 disease research and therapeutic testing. The project will be conducted from September 1, 2024 through August 31, 2027. The Research Institute has extensive experience delivering federal research...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,472,597 to the University of Florida to support cutting-edge research on myotonic dystrophy types 1 and 2. The key objectives are to: 1) accelerate clinical trials for myotonic dystrophy type 1 and advance basic science and translational efforts for type 2 to rapidly...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $459,250 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for a 2-year period from July 2024 to June 2026. The project aims to develop an isogenic human neural stem cell model to isolate and characterize extracellular vesicles, and then use these vesicles to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $532,381 to Emory University to comprehensively investigate the molecular mechanisms underlying the role of the KIF5A gene variant KIF5AΔE27 in the pathogenesis of amyotrophic lateral sclerosis (ALS). The research will involve three specific aims: 1) determining the...
This federal Project Grant award of $438,365 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the role of the CD38 protein in Spinal and Bulbar Muscular Atrophy (SBMA). The research will use stem cell technology and CRISPR-corrected isogenic controls to study metabolic alterations in SBMA patient-derived cells differentiated into...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $226,500.00 to the University of Georgia Research Foundation, Inc. to characterize and treat peripheral nervous system dysfunction in Sanfilippo syndrome (mucopolysaccharidosis type IIIA). The key objectives are to: 1) Develop novel disease models using...
Trustees of Tufts College, doing business as Tufts University School of Medicine, received a $453,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding will support research to define the potential of gene therapy to correct motor disabilities associated with CTNNB1 syndrome, a rare genetic disorder characterized by intellectual...