The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $598,543 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Arkansas for Medical Sciences (UAMS). This grant will support two research projects: Project 1 will investigate the mechanism by which DNA helicase enzymes, which are essential for various cellular processes, can perform multiple functions such as unwinding DNA, unfolding DNA quadruplexes, and remodeling protein-DNA...
The National Institute of General Medical Sciences (NIGMS) has awarded a $349,681 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Maryland, College Park. The grant, effective February 1, 2025 through January 31, 2030, will fund the development of two novel "force nanoprobes" capable of visualizing and quantifying intracellular forces within the genome of living cells. The first nanoprobe uses mechanoluminescence to provide...
The National Institute of General Medical Sciences (NIGMS) awarded a $371,250 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Alabama at Birmingham (UAB). The grant, effective January 1, 2025 through November 30, 2029, supports quantitative studies on the mechanisms of enzyme-catalyzed protein unfolding and translocation by three representative AAA+ molecular motors. The research aims to fill the gap between structural knowledge and...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,637,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Johns Hopkins University to support a 5-year research project titled "Probing the Mechanisms that Control DNA Repair Pathway Choice." The project aims to investigate how chromatin plasticity and RNA modifications regulate DNA repair mechanisms in response to various DNA lesions, with the goal of advancing understanding of...
This $350,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), will support research at Baylor University to understand the dynamic structural changes in enzymes during catalysis. The project aims to apply time-resolved structural biology methods, including millisecond mix-and-quench crystallography and multi-temperature crystallography, to study the structural fluctuations of enzymes...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $390,000.00 to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to conduct research aimed at elucidating the mechanisms underlying DNA double-strand break repair. The research seeks to understand how the multi-enzyme complex that degrades DNA during the DNA repair process is assembled and...
This $294,147 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to advance modeling of macromolecular interactions in living cells. The University of Kansas Center for Research Inc. will apply efficient simulation protocols to characterize the intermolecular energy landscapes and dynamics of different macromolecule types in all-atom representation. This will involve developing new simulation...
The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $355,584 Project Grant to the New Mexico Institute of Mining and Technology (New Mexico Tech) on August 18, 2023. This funding will support research to determine the biochemical basis and functional implications of the interaction between the proteins XRN2 and DDX23, and explore their cooperative role in regulating RNA-DNA hybrid structures...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,675,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Massachusetts Medical School (UMass Medical) to support research focused on two key areas of mammalian nuclear cell biology. The first project involves investigating the role of the tumor marker protein Ki-67 in protecting chromosomes from mitotic damage. Researchers will analyze how Ki-67 binds to and protects DNA, and map...
This $451,802 project grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance the understanding of DNA transcription by cellular and multi-subunit RNA polymerases across bacteria, archaea, and eukaryotes. Over the 5-year project period from February 1, 2025 to January 31, 2030, the research will utilize advanced structural biology techniques such as cryo-electron...