Project Grant R01NS141729
Award Date
9/24/24
Completion Date
8/31/29
Dollars Obligated
$789K
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Boys Town, NE 68010, USA
Similar Awards
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a comprehensive study to determine the prevalence and clinical characteristics of mild cognitive impairment (MCI) and Alzheimer's-related dementia (ADRD) among older adults living with HIV in Uganda. The $1,103,953 award, which began on Sep 15, 2024 and runs through Aug 31, 2025, will fund the following key activities: Comprehensive neuropsychological assessments among 600 older...
This Project Grant award of $1,550,462 from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, supports a 5-year multidisciplinary study investigating Alzheimer's disease (AD) risk factors in older Black/African American adults living with HIV. The study aims to examine the impacts of the APOE E4 gene variant, HIV disease, and their potential interaction on brain function in this vulnerable population, who may face a greater risk of developing Alzheimer's...
This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants aims to evaluate social brain function and its relationship to social functioning in people with HIV (PWH). Using an RDOC-based approach, the project will examine neural circuits and performance related to two core social cognitive constructs: perceiving social cues and understanding others. The project also seeks to investigate the relationships between social...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) federal grant program, will explore the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in the context of chronic HIV infection. The $880,000 award, effective from September 2024 to August 2026, will be administered by Old Dominion University (ODU) and its research foundation. The project aims to investigate the impacts of...
This $1,454,724 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The primary objectives are to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, such as microglia and macrophages. The research will...
This $383,750 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of Nebraska Medical Center (UNMC) to explore the molecular, neuro-immune and behavioral changes that occur during HIV-associated progressive aging using a long-term humanized mouse model. The goal is to determine how HIV latency and antiretroviral therapy (ART) contribute to premature aging, referred to as "LAAGING", and the associated...
This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
This Project Grant award of $263,844 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) aims to track inflammatory macrophage states in mouse models and cerebrospinal fluid of HIV-suppressed individuals to classify neuroinflammation and identify molecular markers associated with cognitive deficits. The project has two key objectives: 1) Determine the spatial distribution of microglia activation states in inflammatory mouse models for aging and HIV...