This $1,008,977 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the development and evolution of the human cerebral cortex. The key objectives are to study human-specific neural progenitor cell types in the outer subventricular zone, which play a critical role in the expansion of the human brain, and explore...
This Project Grant award in the amount of $800,485 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is supporting research to investigate the role of human-specific 3D genome conformation in brain development and disease. The project aims to analyze the spatial genome organization, particularly topologically associated domains (TADs), in human and primate cortical neural progenitor cells and neurons to identify human-specific TAD...
This federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $216,000.00 to the University of California, San Diego (UCSD) to elucidate the function of CTCF, a key protein involved in chromatin organization, in neural differentiation and neurodevelopment. The research will employ both 2D and 3D human cell models to examine the role...
The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $127,145.00 to support research on the regulatory mechanisms governing chromatin organization and gene transcription during neural development in the Drosophila model organism. The key focus areas of the research include: 1) Identifying focal contact anchors that contribute...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $582,883 to the Regents of the University of California at Riverside to study the role of CAS adaptor proteins during cortical axon pathfinding. The research aims to understand how adhesive and instructive signaling pathways are coordinated within neurons during embryonic brain...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $1,341,874.00 to support research on dendrite development, function, degeneration, and regeneration. The research aims to elucidate the molecular mechanisms controlling dendrite formation, understand how mechanosensory channels influence neural function and...
The National Science Foundation Division of Integrative Organismal Systems awarded $799,998 under the Biological Sciences program (CFDA 47.074) to the Regents of the University of California at Riverside. This five-year Project Grant will support research investigating the molecular mechanisms that guide neuronal migration and circuit formation in the developing cerebellum. Key products will include insights from genetic experiments using mouse models to examine the role of CRK-associated...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants provides $237,750.00 to the University of California, Merced to elucidate the neurodevelopmental functions of the SMARCC2 gene, a high-confidence autism spectrum disorder (ASD) candidate, and other subunits of the BAF chromatin remodeling complex. The primary objectives are to determine if the neuronal BAF (nBAF) complex mediates RNA polymerase II elongation...
This $264,600 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to elucidate the mechanisms underlying CBX1-related syndrome, a neurodevelopmental disorder caused by variants in the CBX1 gene that encodes the heterochromatin protein 1 beta (HP1B). The research objective is to investigate how patient-identified CBX1 variants...