This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $582,883 to the Regents of the University of California at Riverside (UC Riverside) to study the role of CAS adaptor proteins during cortical axon pathfinding. The research aims to understand how neurons integrate multiple signaling cues, such as those from adhesion and axon guidance pathways, to establish proper neural circuit connectivity during brain development. Key objectives include exploring the requirement for CAS proteins in cortical axon guidance and fasciculation, elucidating the crosstalk between adhesion and guidance cue signaling, and assessing the impact of disrupted connectivity on cortical processing. The award has a performance period from December 1, 2024 to November 30, 2029, and the research will be conducted at UC Riverside.
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