Project Grant RF1AG072502

Award Date 4/1/21
Completion Date 3/31/24
Dollars Obligated $1.4M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92037, USA
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This $460,625 Project Grant awarded by the National Institute on Aging under CFDA Program 93.866 (Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease. The grant supports research using human induced pluripotent stem cell-based Alzheimer's disease models to dissect the functional consequences of activating the p53/p21 and p16 senescence pathways in differentiated cortical neurons and cerebral organoids. The goal is...
This $522,500 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research by The Salk Institute for Biological Studies in La Jolla, California to investigate the role of astrocytes, a type of brain cell, in age-related motor decline. The research aims to determine if reducing the expression of the STAT1 transcription factor in aged astrocytes can revert aging signatures, rescue synaptic deficits, and improve motor function in the...
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This federal Project Grant award, funded by the National Institute on Aging (part of the Department of Health and Human Services) under the Aging Research program (CFDA 93.866), is focused on evaluating a novel therapeutic approach to target neuroinflammation for protecting against brain aging and Alzheimer's disease-related pathology. The $281,962 award, with an end date of June 30, 2026, will support a series of preclinical studies in aging wild-type mice and transgenic mouse models of amyloid...
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