This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the use of the adipokine adiponectin as a potential therapy to promote functional recovery after traumatic brain injury (TBI). The $571,404 award to the University of Pittsburgh will test the hypothesis that adiponectin receptor activation can mitigate...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the effects of pediatric traumatic brain injury (PTBI) and early life stress on the development of the prefrontal cortex and resulting cognitive function. The $148,700 award to The Ohio State University aims to define acute neuroimmune changes in the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $628,133 Project Grant (CFDA 93.853) to Rutgers, The State University to study the "Metabolic Mechanisms of Recovery in Mild TBI" from September 1, 2024 to July 31, 2028. The research aims to determine if activating the CYPIN protein can promote functional recovery after mild traumatic brain injury (TBI) in mice. This builds on previous work identifying CYPIN as a key molecule regulating methionine levels and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on elucidating the role of metabolic regulation and AMPK activation in modulating neutrophil extracellular traps (NETs) formation and inflammation following traumatic brain injury (TBI). The $453,860 award, with a period of performance from June 1, 2025 to April 30, 2030, will...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" provides $404,100.00 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to study the mechanisms of chronic blood-brain barrier dysfunction after traumatic brain injury (TBI). The research aims to identify a signaling pathway involving the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $587,521.00 to the Regents of the University of Michigan to conduct research on mitigating secondary brain injury following traumatic brain injury (TBI). The key objectives of the research are to: (1) explore the molecular mechanisms of neurotrauma and the therapeutic...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $465,752 to the Regents of the University of Michigan - Dearborn to conduct research on understanding changes in cell chirality and cell-cell interactions within the neurovascular unit (NVU) after traumatic brain injury (TBI). The project aims to evaluate TBI-induced...
This $158,247 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the cell-specific neurodegenerative potential of mitochondria following traumatic brain injury (TBI). The project aims to study how TBI-induced disruptions in mitochondrial function contribute to the development of Alzheimer's-like neurodegeneration over time. Key objectives include determining injury-induced intracellular and extracellular alterations in...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $102,948.00 to Case Western Reserve University to investigate the link between traumatic brain injury (TBI), hematopoietic stem cell dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The key objectives are to assess how acute TBI induces changes to...