Project Grant R01NS138326

Award Date 5/30/25
Completion Date 4/30/30
Dollars Obligated $571K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
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This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $571,404.00 to the University of Pittsburgh to conduct research aimed at understanding and improving neurological outcomes after traumatic brain injury (TBI). The key research objectives are to:

  1. Evaluate the long-term therapeutic potential of an adiponectin receptor agonist in mitigating neurovascular damage and cognitive deficits following TBI, which can increase the risk of developing vascular cognitive impairment and dementia.

  2. Investigate how activating adiponectin receptors may protect against acute axonal injury and hippocampal neuron loss after TBI by stimulating the release of neuroprotective growth factors from microglia, monocyte-derived macrophages, and cerebral endothelial cells.

  3. Assess the role of pro-repair oligodendrocytes and inflammation-resolving microglia/macrophages in facilitating white matter restoration and long-term recovery of cognitive function following severe TBI-induced neurovascular injury.

This 5-year project, starting on May 30, 2025, aims to enhance understanding of the molecular and cellular mechanisms underlying cognitive decline after neurovascular trauma and open new avenues for reducing the risk of vascular cognitive impairment and dementia in TBI patients.

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