This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $517,546 to support the development and validation of a novel multi-modal microelectrode array (MEA) probe. The probe is designed to enable unprecedented integration of fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrophysiological (EPhys) recording. The research team, led by investigators from...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to elucidate the neural substrates underlying novelty-related social investigation behaviors in mice. The $196,460 project, awarded to Emory University and running from December 1, 2024 to May 31, 2027, will leverage advanced in vivo recording techniques, projection-specific optogenetic stimulation, and computational approaches to understand...
The National Institute of Mental Health (NIMH) awarded a $633,438 Project Grant (CFDA 93.242 Mental Health Research Grants) to New York University to develop a data-driven framework for real-time neural control and targeted modulation of primate prefrontal cortical circuits. The key objectives are to investigate the principles governing multi-electrode microstimulation patterns and their effects on neural population activity, introduce a novel data-driven algorithm to predict optimal stimulation...
The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is providing $107,948.00 to The Johns Hopkins University to study the computational mechanisms underlying single neuron activity within brain-wide circuits. The research aims to characterize the relationships between synaptic input patterns and action potential generation in cortical neurons, investigate how inputs change when the brain drives specific neuron...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 "Mental Health Research Grants" will establish a platform to accurately recapitulate and perturb cortical development and morphogenesis in vitro. The $679,072 award to President and Fellows of Harvard College will enable the development of innovative bioengineering methods to generate organoids with correctly integrated choroid plexus, cortical hem, layered cortex, and ventral inhibitory...
The federal Project Grant award of $461,084.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research by Yale University to elucidate how POMC neurons in the hypothalamus respond to social cues and regulate social behaviors during development. The overarching goal is to gain cellular and circuit-level insights into how the developing brain regulates age-specific social behaviors. Key research activities include mapping...
This federal Project Grant award of $135,989 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to comprehensively map the influence of gonadal hormones on network-level coding of proactive social behavior and related variables, and identify sites of in vivo hormonal action. The research aims to unravel the neuroendocrine mechanisms that promote proactive social behavior, a critical step toward understanding the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $301,524 to The Trustees of Princeton University to investigate the neural encoding of distinct social drives in the ventrolateral area (VMHvl) of the hypothalamus. The research aims to determine if and when social choices can be predicted from VMHvl neural...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $481,250 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to President and Fellows of Harvard College. The grant's objective is to develop a synthetic biological system that can manipulate subcellular RNAs and proteins in a subtype- and context-specific manner within neurons. This system aims to enable novel investigations of how subcellular...
This $120,015 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the neural mechanisms underlying homeostatic, physiological, and social behaviors. The awardee, President and Fellows of Harvard College, will develop a novel technological pipeline to monitor large-scale neural activity in freely moving animals and identify the transcriptomic identities of individual neurons. This approach aims to reveal how unique transcriptomic axes shape the neural dynamics that encode homeostatic states and social behaviors in the lateral hypothalamus and periaqueductal gray regions of the brain. The grant period runs from January 6, 2025 to December 31, 2026.