Project Grant DP2MH136494
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is supporting research to develop a highly optimized two-photon (2P) multiplexing system for enabling high-fidelity, large-scale voltage imaging of neuronal activity in vivo. The $768,000 grant, awarded on September 20, 2025, aims to address the technical challenges of current voltage imaging techniques, which have been limited to small neuron...
- The National Institute of Mental Health (NIMH) awarded a $980,661 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Neuralthread Inc. to develop a fully integrated "TULLEKIT" system for stable, high-density neural recordings in freely moving non-human primates (NHPs). The TULLEKIT platform combines ultraflexible 384-channel probes, a minimally invasive port system for deep-brain implantation, and a wireless recording headstage to address key challenges in...
- The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
- The National Institute of Mental Health (NIMH) awarded a $314,113 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Physical Sciences Inc. (PSI) of Andover, MA. The grant will fund the development and demonstration of a high-speed, multicolor confocal fluorescence imager to simultaneously capture multi-wavelength signals and display them as separated or merged multicolor images and 3-D stacks. This technology innovation will enable mapping of complex neuronal network...
- This $1,344,223 Project Grant awarded by the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding research to develop a novel nanomaterial-based platform for noninvasive neuroengineering. The key objectives are to: Engineer ultra-bright upconversion nanoparticles that can convert near-infrared light into visible light for deep brain optogenetic stimulation. Leverage focused ultrasound to deliver the nanoparticles across the...
- This Project Grant award of $517,546, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to optimize, benchmark, and validate a novel multimodal microelectrode array (MEA) probe that integrates fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrical recording. The research team, led by investigators from Dartmouth College, aims to develop this integrated MEA platform...
- The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...
- This $449,228 Project Grant from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will enable Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for large-scale, chronic extracellular neural recording and stimulation in human brain organoids. The project aims to 1) create advanced biological assay chambers to support chronic electrophysiology while maintaining organoid health, 2) develop...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is for the development and commercialization of an automated platform for high-throughput behavioral and electrophysiology research in freely behaving rats. The $1,266,318 award to Spikegadgets, Inc., a neuroscience research equipment company based in San Francisco, CA, will fund the creation of an integrated system that can administer operant...
- This Project Grant award, valued at $120,015.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research by the President and Fellows of Harvard College to develop a novel technological pipeline that enables the monitoring of large-scale neural activity in freely moving animals and the identification of the transcriptomic identity of the same individual neurons. This research aims to achieve a...
Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes sensory information and guides actions. The "NET-2P" system being developed comprises a 3D nanoelectrode array integrated with a mini two-photon microscope, weighing only 3.5 grams. This will allow for rapid electrical mapping across large cortical areas while providing optical access for cellular-level imaging in freely behaving mice. The research aims to study cortical traveling waves and ensemble activity during tactile processing and sleep-related memory consolidation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 8/16/23 |