Project Grant R01MH140813
- The National Institute of Mental Health awarded the University of California, Los Angeles $772,569 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct highly parallel analysis of high-confidence autism spectrum disorder and schizophrenia risk gene mechanisms. The recipient will study approximately 50 risk genes identified as harboring rare, protein-disrupting heterozygous mutations associated with these neuropsychiatric disorders. The work leverages a...
- The National Institute of Mental Health awarded $442,750 to the University of California, Davis on July 1, 2026 under the Mental Health Research Grants program (CFDA 93.242) to investigate synaptic plasticity and signaling mechanisms in 22Q11.2 deletion syndrome model mice. The research addresses learning and memory deficits in 22Q11.2 deletion syndrome, the most common chromosomal microdeletion in humans (incidence approximately 1 in 4,000 live births), which presents broad symptoms including...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $832,307 on April 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research into the genetic control of basal telencephalic development and the transcriptional and epigenetic mechanisms governing forebrain GABAergic neuron differentiation. The research addresses dysregulation of basal ganglia and cortical development as a central factor in epilepsy,...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $734,707 on August 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the coordinated maturation of neurons and synapses in the adolescent human neocortex. The research develops a pipeline to retrieve and analyze tissue specimens resected during pediatric neurosurgical procedures for epilepsy, vascular malformations, or brain tumors. The study examines whether postnatal...
- The National Institute of Mental Health awarded Yale University $157,388 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to functionally characterize somatic mosaic variants in the brains of patients with schizophrenia and autism and determine their causal roles in neurodevelopmental disease. The funded work applies massively parallel reporter assays, CRISPR technology, and human induced pluripotent stem cell-derived neural progenitor cells and post-mitotic neurons...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $534,191 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop robust fine-mapping tools for genetic discovery in neuropsychiatric traits using deep phenotype data from diverse populations. The project addresses the challenge of understanding genetic causes of complex neuropsychiatric conditions including autism spectrum disorders, bipolar disorder, and...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $528,000 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support developmental characterization of synapses between neurons and oligodendrocyte precursor cells. The funded research investigates structural, functional, and molecular properties of neuron-OPC synapses, a class of synaptic connections that remain poorly understood despite evidence that oligodendrocyte precursor cells...
- The National Institute of Mental Health awarded The Washington University $763,894 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ZNF292 gene in cortical development and neurodevelopmental disorders. The research employs complementary experimental systems—mouse knockout models and human pluripotent stem cell-derived neurons carrying six pathogenic ZNF292 variants identified in patients with autism spectrum disorder, intellectual...
- The National Institute of Mental Health awarded the University of Pittsburgh $751,430 on August 4, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a multi-omic atlas of dendritic spine morphometry across postnatal development in neurotypical and autism spectrum disorder subjects. The research interrogates trajectories of synaptic protein network features—protein expression, synaptosome levels, and phosphorylation—in the prefrontal cortex and primary visual...
The National Institute of Mental Health awarded University of California, Los Angeles $764,785 under the Mental Health Research Grants program (CFDA 93.242) on July 16, 2026, to investigate context-dependent disease mechanisms in neurodevelopmental disorders, specifically the 16p11.2 chromosomal deletion (16PDEL) implicated in autism, intellectual disability, and ADHD. The project will use a proprietary in vitro human stem cell platform called the Cell Village to conduct high-throughput molecular and cellular analysis of how fetal brain cells derived from 16PDEL patient donors respond to developmental signaling pathway stimulation. The research integrates multi-omic datasets to uncover mechanistic links between gene expression, cellular phenotypes, and pathway activation in 16PDEL brain cells, comparing results against neurotypical control cell lines. This approach aims to identify biological signatures of pathology that can inform experimental neuroscience paradigms and potential interventions for core symptoms of these disorders. Performance occurs at Los Angeles, California (UCLA's Office of Research Administration). The period of performance runs through April 30, 2031. The assistance type is a project grant, which under the Mental Health Research Grants program provides support for specified project periods not to exceed five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $764.8k | 7/20/26 |