The National Institute of Mental Health (NIMH) awarded a $908,174 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Lieber Institute for Brain Development to conduct research on understanding the etiology and pathophysiology of schizophrenia. The 5-year grant (8/7/2024 - 4/30/2029) will utilize induced pluripotent stem cell (iPSC) technology to model the cellular effects of common schizophrenia genetic risk variants. The research will involve phenotypic discovery on cortical...
This R01 Project Grant, awarded by the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants, is funding a $1,854,632 research study at the Children's Hospital of Philadelphia (CHOP) from July 2024 to January 2027. The project aims to investigate the links between mitochondrial dysfunction, synaptic impairment, and the development of schizophrenia. Specifically, the researchers will study mitochondrial biogenesis, mitophagy, and glutamatergic synaptic release...
This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...
This federal Project Grant award of $430,375.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research by Emory University to investigate neurogenic defects in cellular models of Fragile X Syndrome. The project aims to determine if cyclic AMP signaling is disrupted during early brain development in Fragile X Syndrome and whether targeting the microtubule-associated protein Doublecortin could have therapeutic...
This $731,035 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, supports research to investigate the neural circuit dysfunction underlying auditory hallucinations in a mouse model of 22q11.2 deletion syndrome, a genetic disorder associated with a high risk of schizophrenia. The key objectives are to: 1) Test if mimicking 22q11.2 deletion abnormalities, such as reducing thalamic output and increasing...
This $429,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate the molecular mechanisms underlying dysregulation of inhibitory gabaergic synapses in Down syndrome. The research will utilize human embryonic stem cell models to study how overexpression of the Down syndrome cell adhesion molecule (DSCAM) gene, resulting from trisomy 21,...
The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA to conduct scalable functional analysis of neuropsychiatric risk genes using spatially integrated in vivo perturb-seq technology. This 5-year research project aims to comprehensively map the functions of 72 high-confidence autism spectrum disorder and neurodevelopmental delay (ASD/NDD) risk genes in the neocortex and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $157,000.00 to the University of California, Irvine to conduct research on the dopaminergic control of glial cells in the prefrontal cortex. The goal is to determine the impact of D2 receptor signaling in astrocytes on prefrontal cortex functions, gene expression, and metabolite production. The project will use viral vectors to knockdown D2 receptors...
This Project Grant award from the National Institute of Mental Health (NIMH), under the agency's Mental Health Research Grants program (CFDA 93.242), will provide $1,380,070 to Duke University to conduct research on the cellular properties and circuit functional roles of human cortical interneurons. The research seeks to generate a multimodal phenotypic catalog of human interneurons and characterize their functional organization in neural circuits. This work aims to advance strategies for...
This Project Grant award in the amount of $246,000.00 was provided by the National Institute of Mental Health (NIMH) under the Federal Grant Program "Mental Health Research Grants" (CFDA 93.242). The funding supports research conducted by The University of Texas Southwestern Medical Center (UT Southwestern) aimed at deciphering age-dependent hippocampal hyperactivity and its implications for psychogenesis. The research project utilizes chemogenetic techniques to gradually inhibit...