Project Grant R01MH140482

Award Date 4/15/25
Completion Date 3/31/30
Dollars Obligated $822K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Texas, USA
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This $821,998 Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 (Mental Health Research Grants) aims to enhance the efficiency and specificity of non-viral methods for delivering molecules, such as genes, proteins, and chemicals, into neurons across diverse species. The key products and services to be delivered include:

  1. Characterizing the range of molecules that can be delivered by the N1 peptide, which exhibits strong neuron-targeting capabilities, and evaluating its efficacy for neuron-specific delivery across multiple animal models.

  2. Investigating the mechanisms underlying the neuron-targeting properties of the N1 peptide, including identifying potential binding partners and receptor molecules.

  3. Optimizing the N1 peptide through structure-activity relationship studies, conformational constraint, and improving metabolic stability for enhanced delivery capabilities.

  4. Exploring non-invasive delivery methods, such as intrathecal injection and ultrasound-assisted approaches, to enable potential translational applications in the human nervous system.

  5. Investigating the delivery of small molecules for neuron imaging and perturbation to support both basic and translational neuroscience research.

This comprehensive research program, awarded to the University of Texas at Dallas, has the potential to significantly impact the field of neuroscience by enabling more efficient and targeted delivery of diverse molecules into neurons across species, with significant implications for human therapeutics.

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