This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a $424,875 research project titled "Adolescent Trauma Produces Enduring Disruptions in Sleep Architecture that Lead to Increased Risk for Adult Mental Illness." The project aims to: 1) determine if individual differences in sleep profiles following adolescent stress can predict adult behavioral outcomes related to depression and...
This federal Project Grant award of $408,541 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the role of retrosplenial cortex (RSC) neurons in initiating slow-wave sleep (SWS) transitions and facilitating memory consolidation. The key objectives are to: 1) Investigate the neural dynamics of RSC layer-5 neurons in memory consolidation, and 2) Examine the connectivity and causal role of RSC...
This $665,893 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand how hippocampal activity during sleep affects the stabilization and interference of context-specific memories. The primary awardee, the Regents of the University of Michigan, will conduct experiments to develop advanced machine learning techniques for analyzing hippocampal neuronal activity during sleep, with the...
This $176,180 federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research at the University of Pittsburgh to investigate the neurobiological mechanisms underlying emotional responses to acute psychological stress. The funded study will use noninvasive neuromodulation techniques, such as continuous theta burst stimulation (cTBS), combined with functional neuroimaging, to examine the causal...
This $1,201,659 federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) will support research on the mechanisms and consequences of infraslow oscillations in sleep. The award, with a period of performance from September 15, 2024 to May 31, 2029, will be led by the University of Pennsylvania with sub-awards to the University of Michigan and Colorado School of...
This federal Project Grant award of $606,029.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the neurocircuitry underlying motivated reward-seeking behavior in response to stress. The key goals of the research are to: 1) Determine if a subpopulation of GABAergic neurons in the medial habenulo-interpeduncular (MHB-IPN) axis...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $719,917 to investigate the effects of chronic stress on cognitive flexibility and the underlying cellular mechanisms in the prefrontal cortex. The key objectives are to: Examine sex-dependent effects of chronic stress on cognitive flexibility and related changes in synaptic regulation and activity of specific neuronal subpopulations in the...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to examine the mechanistic pathways between sleep patterns and positive valence systems (PVS) in social and non-social contexts during pre-adolescence. The $1,432,724 award, effective September 10, 2024 through June 30, 2029, will support two studies: Study 1 is a 1-year longitudinal study with 290 youth ages 8-12 to assess objective sleep...
This Project Grant award in the amount of $181,234 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research to study the impact of early psychostimulant exposure on sleep neurophysiology and circadian rhythms in animal models of Attention-Deficit/Hyperactivity Disorder (ADHD). The research aims to break down the complex relationship between ADHD, psychostimulant medications like methylphenidate, and their...
The National Institute of Mental Health (NIMH) awarded a $715,662 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Trustees of the University of Pennsylvania to investigate the epigenetic mechanisms underlying stress vulnerability and the pathogenic mechanisms linking stress to increased susceptibility of psychiatric conditions. The research aims to improve understanding of the underlying causes of stress-related psychiatric disorders and provide a foundation for better...