The National Institute of Mental Health (NIMH) awarded a $392,500 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the Research Institute at Nationwide Children's Hospital. The 2-year award, beginning May 1, 2025, will fund research to characterize the role of sleep brain dynamics in the emergence of depression in adolescents. The study aims to: 1) identify the space-time profiles of slow oscillations and sleep spindles and compare them across youth at high and...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a $424,875 research project titled "Adolescent Trauma Produces Enduring Disruptions in Sleep Architecture that Lead to Increased Risk for Adult Mental Illness." The project aims to: 1) determine if individual differences in sleep profiles following adolescent stress can predict adult behavioral outcomes related to depression and...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $162,486 to the University of Illinois to conduct research on the role of sleep in the premenstrual exacerbation of depression and suicidality. The 4-year project will utilize high-resolution digital health sleep data from a recently completed clinical trial to identify periods of acute suicide risk and potential sleep-related treatment targets,...
The National Institute of Mental Health (NIMH) awarded a $2,809,928 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh to conduct a multi-site, double-blind, randomized-controlled efficacy trial of a transdiagnostic intervention for sleep and circadian dysfunction to improve depression symptoms in older adults with high suicide risk. The study aims to confirm the target engagement and efficacy of this intervention, as well as develop an algorithm to...
This Project Grant award of $633,671 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, supports research on the safety of prescription sleep medications in children, adolescents, and young adults with Attention Deficit Hyperactivity Disorder (ADHD). The key objectives are to: 1) Evaluate nationwide patterns of prescription sleep medication use and dose-escalation in youth with ADHD; 2) Determine the extent to which these...
This $793,161 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a 5-year experimental study to investigate the relationship between nocturnal wakefulness and suicide risk factors. The University of Arizona, the prime awardee, will recruit 90 adults with recent suicidal ideation to participate in laboratory-based assessments of cognitive processes and affect at different times of day, as well as...
This Project Grant award of $1,135,986, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to clarify suicide risk phenotypes among preteen youth aged 8-12 years old. The primary objectives are to: Adapt an existing measure of suicide risk for use with preteens, incorporating expert and stakeholder input to ensure cultural and developmental appropriateness. Use the new measure to establish phenotypes of...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a $121,424 study examining the relationship between early sleep disruption, functional brain networks, and developmental trajectories in infancy. The study will leverage data from two longitudinal NIH-funded projects - the Infant Brain Imaging Study (IBIS) and the Healthy Brain and Child Development (HBCD) Study - to (1) investigate how...
This Project Grant award from the National Institute of Mental Health (NIMH, CFDA 93.242 Mental Health Research Grants) provides $588,018 to The Trustees of the University of Pennsylvania to investigate the neural basis of how stress impacts sleep architecture and cognition. The key focus is to determine how inputs from stress-regulatory neurons in the locus coeruleus and paraventricular nucleus of the hypothalamus disrupt specific features of sleep, such as microarousals and REM sleep...
This federal Project Grant award of $826,902 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the dynamic relationships of physical activity, sleep, and circadian rhythms with heterogeneity in clinical symptoms and neurobehavioral functioning in children with Attention-Deficit/Hyperactivity Disorder (ADHD). The award will fund a micro-longitudinal study leveraging wearable technology to objectively track daily...
The National Institute of Mental Health (NIMH) awarded a 5-year, $2,052,679 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Montana State University to study the developmental impacts of sleep patterns on positive valence systems and socioemotional functioning in pre-adolescent youth.
The research will examine the mechanistic pathways between behavioral and neurophysiological sleep patterns and positive valence systems in social and non-social contexts during pre-adolescence. This will be accomplished through a longitudinal study monitoring sleep, daily activities, social interactions, and reward-related behaviors in a non-clinical sample of 290 youth aged 8-12, as well as an experimental sleep restriction protocol in a separate sample of 64 non-clinical youth aged 10-12. The goal is to better understand how sleep patterns during this critical developmental period impact the neural systems underlying reward, motivation, and social functioning, which can inform prevention and treatment efforts for mental health disorders.